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Full-Text Articles in Life Sciences
Understanding Acquired Resistance To Lapatinib In Breast Cancer Cells, Jen-Te Tseng
Understanding Acquired Resistance To Lapatinib In Breast Cancer Cells, Jen-Te Tseng
Dissertations & Theses (Open Access)
Signaling through epidermal growth factor receptor (EGFR/ErbB) family members plays a very important role in regulating proliferation, development, and malignant transformation of mammary epithelial cells. ErbB family members are often over-expressed in human breast carcinomas. Lapatinib is an ErbB1 and ErbB2 tyrosine kinase inhibitor that has been shown to have anti-proliferative effects in breast and lung cancer cells. Cells treated with Lapatinib undergo G1 phase arrest, followed by apoptosis. Lapatinib has been approved for clinical use, though patients have developed resistance to the drug, as seen previously with other EGFR inhibitors. Moreover, the therapeutic efficacy varies significantly within the patient …
Regulation Of Crbp1 In Mammary Epithelial Cells, Stacy L. Pease
Regulation Of Crbp1 In Mammary Epithelial Cells, Stacy L. Pease
Masters Theses 1911 - February 2014
Breast cancer is the second leading cause of death of women in the United States, warranting further investigation into preventative therapies. It has been well documented that early pregnancy results in a lifetime decreased risk of breast cancer in humans and mounting evidence suggests that the retinoic acid pathway may play an important role in this protective effect. Cellular retinol binding protein-1 (CRBP1) is an essential component of the retinoic acid pathway and we propose that it plays an important role in pregnancy-induced protection against breast cancer. In order to investigate the role of CRBP1 in parity-induced protection against breast …