Life Sciences Commons^™

Dexterous Manipulation Capabilities Are Associated With Change In Discharge Rate Properties Of Motor Neurons With Age, Mukta N. Joshi

Theses and Dissertations

Aging is accompanied by declines in manual dexterity and fine motor control. The purpose of this research was to compare hand motor control in young and older adults and examine the neuromuscular mechanisms responsible for enabling these interactions. We test force variability during isometric and dynamic contractions, manual dexterity and track motor unit activity to identify the neuromuscular mechanisms responsible for changes in dexterity with age. 26 older adults (66-86 years) and 28 young adults (19 – 38 years) participated in the study. Research participants performed force matching tasks during index finger abduction, precision pinch, static pressing and hybrid force/ …

Sex Differences And Physical Activity Status On The Hamstring: Quadriceps Ratio, Activities Of Daily Living, And Functional Movement In Older Adults, Brittany N. Followay, Haley A. Reierson, Emily M. Rigden

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 1228-1243, 2023. The study aimed to investigate sex differences and the effect of physical activity on the hamstring:quadriceps (H:Q) ratio, activities of daily living (ADLs), and the Functional Movement Screen (FMS) in older adults. Thirty older adults (72.56 + 6.22) completed maximal voluntary isometric contractions (MVICs), ADLs, the FMS, and three closed-kinetic chain exercises (CKCs); front lunge (FL), side lunge (SL), and bilateral squat (BLSQ). Electromyography was recorded from the biceps femoris (BF) and vastus lateralis (VL) on the dominant and non-dominant limbs during the MVICs …

Quantifying Balance: Computational And Learning Frameworks For The Characterization Of Balance In Bipedal Systems, Kubra Akbas

Dissertations

In clinical practice and general healthcare settings, the lack of reliable and objective balance and stability assessment metrics hinders the tracking of patient performance progression during rehabilitation; the assessment of bipedal balance plays a crucial role in understanding stability and falls in humans and other bipeds, while providing clinicians important information regarding rehabilitation outcomes. Bipedal balance has often been examined through kinematic or kinetic quantities, such as the Zero Moment Point and Center of Pressure; however, analyzing balance specifically through the body's Center of Mass (COM) state offers a holistic and easily comprehensible view of balance and stability.

Building upon …

Effects Of Parkinson’S Disease On Motor Asymmetry, Deborah Mazanek Watson

Theses and Dissertations

Introduction: Persons with Parkinson’s disease (PD) experience changes cortically, subcortically and behaviorally. This dissertation examines the asymmetry of motor behavior to explore the role of asymmetry in persons with PD and its connection to clinical symptoms. Purpose: Project 1: To assess the hand asymmetry difference in young adults versus older adults. Project 2: To investigate the difference in hand asymmetry in older adults and persons with PD. Project 3: To explore the correlation between function and clinical symptoms of persons with PD. Methods: 55 right-handed participants [Young Adults (YA) = 20, Female = 10; Older Adults (OA) = 20, Female …

Obstacle Crossing In Healthy Young And Older Individuals, Hope M. Hanson, Ashlyn M. Jendro, Abigail C. Schmitt

Health, Human Performance and Recreation Undergraduate Honors Theses

Introduction: In the United States, the average population age is rising and will continue to increase in the coming years.With an older population comes increased risk of injury associated with falls. Falls are considered a leading cause of injury and death in older individuals, and many falls are caused by body imbalance or obstacle collision due to a clearly visible stationary object (e.g., rug, chair, branch). Older adults tend to cross obstacles with increased toe clearance in order to prevent tripping, but much of what is known about obstacle crossing in older adults is limited to artificial obstacles that are …

Short-Term Removal Of Exercise Impairs Glycemic Control In Older Adults: A Randomized Trial, Leryn J. Reynolds, Troy M. Williams, Joel E. Harden, Hannah M. Twiddy, Monica L. Kearney

Human Movement Sciences Faculty Publications

Postprandial glycemia (PPG) predicts cardiovascular disease, and short-term physical inactivity increases PPG in young, active adults. Whether this occurs in older, active adults who may be more prone to bouts of inactivity is unknown. This study determined if postprandial interstitial glucose (PPIG) was impaired in active older adults following the removal of exercise for 3 days (NOEX) compared to active young adults. In this randomized, crossover study, 11 older (69.1 ± 1.9 years) and 9 young (32.8 ± 1.8 years) habitually active (≥90 min/week of exercise) adults completed 3-days of NOEX and 3-days of normal habitual exercise (EX), separated by …

Probiotic Bc30 Improves Amino Acid Absorption From Plant Protein Concentrate In Older Women, Kylie E. Walden, Anthony M. Hagele, Logan S. Orr, Kristen N. Gross, Joesi M. Krieger, Ralf Jäger, Chad M. Kerksick

Faculty Scholarship

Weizmannia coagulans GBI-30, 6086 (BC30) has previously been shown to increase protein digestion in an in vitro model of the stomach and small intestine and amino acid appearance in healthy men and women after ingestion of milk protein concentrate. The impact of ingesting BC30 with other protein sources or in other demographics is largely unknown. The purpose of this study was to examine the impact of adding BC30 to a 20-g dose of a blend of rice and pea protein on postprandial changes in blood amino acids concentrations in healthy, older women. Healthy, older females (n = 30, 58.5 …

The Effect Of Postural Perturbations On Cardiovascular And Skeletal Muscle Function In Healthy Adults, Patrick Siedlecki

Electronic Thesis and Dissertation Repository

Maintenance of standing balance is vital to daily living. Traditionally, perspectives on maintaining balance are achieved through the study of visual, vestibular and somatosensory inputs on motor outputs. While evidence suggests cardiovascular regulation also functions to assist postural control during orthostatic stress, how the cardiovascular system responds to postural perturbations is not well established. This dissertation includes four studies that investigated the effects of postural perturbations on the cardiovascular system and skeletal muscle responses in healthy adults. All of the studies involved exposing standing participants to surface-translation perturbations at different velocities, with known or unknown timing, and occurred while spontaneously …

Functional Benefits Of Hard Martial Arts For Older Adults: A Scoping Review, Ian Miller, Mike Climstein, Luke Del Vecchio

International Journal of Exercise Science

International Journal of Exercise Science 15(3): 1430-1443, 2022. The present scoping review focused upon the functional benefits of hard martial arts training for older adults. The AXIS Critical Appraisal Tool was used to appraise all studies included in the review. A systematic literature search identified 265 papers via electronic database and ten papers from additional sources. Of these, six studies featuring 240 participants were included in the final scoping review. Of the included studies, three were randomized control trials and three were comparative studies with concurrent controls. The available studies outlined improvements in functional fitness parameters for older adults participating …

Functional Neuroimaging Techniques To Examine Falls And Cognition In Older Adults: A Systematic Review, Tia M. Seleem, Raphael Gabiazon

Undergraduate Student Research Internships Conference

Falls in older adults have been attributed to impaired cognition. There is potential for neuroimaging techniques to understand the biological components that are involved in the cognitive processes pertaining to falls. Therefore, the purpose of this systematic review was to analyze how functional neuroimaging can be used to examine the relationship between falls and cognition among older adults. The following five electronic databases were selected to identify peer-reviewed articles in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: 1) Medline (via OVID), 2) PsycINFO (via OVID), 3) CINAHL (via EBSCO), 4) EMBASE (via OVID), and 5) Pubmed. …

Effects Of Aging On Patellofemoral Joint Stress During Stair Negotiation On Challenging Surfaces, Nicholas Lynn Hunt

Boise State University Theses and Dissertations

Introduction: Patellofemoral pain is an incessant lower limb musculoskeletal disorder that may be underreported in older adults. During common locomotor activities, such as when negotiating stairs, older adults (over the age of 65 years) adopt knee biomechanics reported to increase patellofemoral pain. Negotiating stairs with a challenging surface, such as uneven or slick, may place greater demand on the knee and further exacerbate joint biomechanics related to PFJ stress. Yet, it is unknown if older adults exhibit increases in patellofemoral joint (PFJ) stress when negotiating stairs with challenging surfaces. Purpose: The purpose of this study was to examine the effect …

Inflammaging: Inflammatory Biomarkers Associated With Nutrition, Metabolism And Muscle Tissue Oxygenation Relative To Sarcopenic Status In Older Adults, Marni Elise Shoemaker

Open Access Theses & Dissertations

The purpose of this study is to examine if we can differentiate inflammaging between sarcopenic and non-sarcopenic older adults by exploring if there are differences between biomarkers of inflammation and nutritional status in older adults with distinct differences in skeletal muscle mass, strength, and function, metabolic flexibility, and muscle tissue oxygenation. Twenty-one non-sarcopenic (mean±standard deviation, age = 73.1±6.2 yrs, n=5 males, n=5 females) and sarcopenic (age = 81.2±10.5 yrs, n=6 males, n=5 females) were categorized based on muscle mass and strength criteria according to the European Working Group on Sarcopenia in Older People. Body composition, handgrip and leg extension strength, …

Age-Related Changes In Corticospinal Drive During Locomotor Adaptation, Sumire D. Sato

Doctoral Dissertations

During activities of daily living, locomotor patterns must be continuously adapted according to changes in our body (e.g., bodily injuries, fatigue) and to the changing environment (e.g., walking surface). Plasticity of spinal networks and supraspinal centers, including the cerebellum and cerebral cortex, have been shown to play important roles in human locomotor adaptation. However, the neural control of locomotion and the ability to adapt locomotor patterns are altered in older adults, which may limit activities of daily living and increase fall-related injuries in the elderly population. My dissertation project is focused on understanding the role of corticospinal drive during split-belt …

Acute Effects Of Velocity-Based Resistance Training On The Physical Functional Performance Of Older Adults, Suzy S. Pinto, Ewertton S. Bezerra, Keuly G. Silva, Rodrigo Ramirez-Campillo, Abderaouf B. Abderrahman

International Journal of Exercise Science

International Journal of Exercise Science 15(3): 399-413, 2022. The aim of this study was to analyse the acute effects of velocity-based resistance training on the physical and functional performance of older adults. Twenty participants (70.4 ± 7.4 years) performed the deadlift exercise, in two different resistance training protocols. The moderate-velocity protocol (MV) predicted maximum loads so that the movement velocity during the concentric phase remained in the range of 0.5 to 0.7 m/s and the high-velocity protocol (HV) predicted maximum loads so that the movement velocity remained between 0.8 and 1.0 m/s. The jump height (cm), handgrip strength (kg), and …

“The Vehicle Was A Hockey Game”: A Holistic Approach To Aging For Older Men, Ryan Tomaselli

Electronic Theses and Dissertations

The many benefits of physical activity are well established. Nonetheless, there remains a need for qualitative research on aging and sports focused on the normalization of sport for older adults, and the increased opportunity for sport participation in older age. Aging and sport research, which has primarily focussed on older elite athletes, has found older adults value health-related benefits, social interaction, and resistance of the aging process through sport participation. However, research examining a broader scope of specific sport participation, such as hockey, in older age may provide a distinguished understanding of participation tied to meaning and lifestyle factors. Therefore, …

Allowing The Experiences Of Older Adults To Be Heard: Interpreting Senior Centre Accessibility, Fallon Mitchell

Electronic Theses and Dissertations

Senior centres aim to support and improve the health of older adults by offering a wide variety ofservices and activities tailored to their needs, yet there is little known about accessibility of senior centres. Inaccessible environments can negatively impact participation and health potentially leading to increased sedentary behaviour and morbidity. This study explores the accessibility experiences of older adults through a case study of a senior centre in Southwestern Ontario. This study utilizes a hermeneutic phenomenological approach to ascertain a deeper understanding of the participants’ lived experiences. Six older adult members (m = 2, f = 4; Mage = 72 …

Comparison Of Constant Load Exercise Intensity For Verification Of Maximal Oxygen Uptake Following A Graded Exercise Test In Older Adults, Ian R. Villanueva, John C. Campbell, Serena M. Medina, Theresa M. Jorgensen, Shannon L. Wilson, Siddhartha S. Angadi, Glenn A. Gaesser, Jared M. Dickinson

All Faculty Scholarship for the College of Education and Professional Studies

Maximal oxygen uptake (VO₂max) declines with advancing age and is a predictor of morbidity and mortality risk. The purpose here was to assess the utility of constant load tests performed either above or below peak work rate obtained from a graded exercise test for verification of VO₂max in older adults. Twenty-two healthy older adults (9M, 13F, 67 ± 6 years, BMI: 26.3 ± 5.1 kg·m⁻²) participated in the study. Participants were asked to complete two experimental trials in a randomized, counterbalanced cross-over design. Both trials (cycle ergometer) consisted of (1) an identical graded exercise …

Postprandial Exhaled Nitric Oxide Responses In Older And Younger Adults With And Without Acute Exercise, Molly Miller

Masters Theses, 2020-current

A single high fat meal (HFM) increases airway inflammation in young, healthy individuals. Additionally, aging increases airway resistance and inflammation, though the airway inflammatory response to a HFM has not been investigated. Exercise is a natural anti-inflammatory, but has yet to be administered with a HFM as a method to study postprandial airway inflammation in older adults. Purpose: To investigate whether older individuals have greater postprandial airway inflammation compared to younger counterparts, and to explore whether exercise may modify the postprandial airway response in older adults. Methods: 12 younger adults (23.3±3.9 years; 5 M/7 F) and 12 older adults (67.7±6 …

Muscle Performance Changes With Age In Active Women, Ryan M. Miller, Eduardo D. S. Freitas, Aaron D. Heishman, Keldon M. Peak, Samuel R. Buchanan, J. Mikhail Kellawan, Hugo M. Pereira, Debra A. Bemben, Michael G. Bemben

Health & Human Performance Faculty Publications and Presentations

The purpose of this study was to examine age-related differences in muscle performance in women divided into young (YW, 20–39 years, n = 29) middle-aged (MAW, 40–59 years, n = 33), and older (OW, ≥60 years, n = 40) age groups. Methods: Hand grip strength, vertical jump performance, and knee extensor (KE) strength (0 deg/s, 60 deg/s, and 240 deg/s), speed of movement (SoM; at 1 Nm, 20%, 40%, and 60% isometric strength), and endurance (30-repetition test at 60 degs/s and 240 deg/s) were assessed. Computed tomography-acquired muscle cross-sectional area (mCSA) was measured and included to determine specific strength (KE …

Self-Selected Maximum But Not Jogging Speed Decreases With Age In Male And Female Runners, Heather Hamilton, Rumit Singh Kakar

College of Health Sciences Posters

Introduction: Running velocity decreases with age, likely resulting from physiological and musculoskeletal changes associated with aging. Females experience a more rapid decline in physical performance during middle age than males, therefore it is important to consider separate-sex analyses when studying running biomechanics and running-related injury. The purpose of this study was to determine the relationship between age and different running speeds separately for female and male runners.

Methods: Male (n=33) and female (n=46) runners (ages 18–65 years) ran at their self-selected JOG (long distance) and MAX (maximal running) pace on a treadmill. Running velocity was recorded. Simple linear regression was …

Gait Complexity Is Acutely Restored In Older Adults When Walking To A Fractal-Like Visual Stimulus, Joao R. Vaz, Brian Knarr, Nicholas Stergiou

Journal Articles

Typically, gait rehabilitation uses an invariant stimulus paradigm to improve gait related deficiencies. However, this approach may not be optimal as it does not incorporate gait complexity, or in more precise words, the variable fractal-like nature found in the gait fluctuations commonly observed in healthy populations. Aging which also affects gait complexity, resulting in a loss of adaptability to the surrounding environment, could benefit from gait rehabilitation that incorporates a variable fractal-like stimulus paradigm. Therefore, the present study aimed to investigate the effect of a variable fractal-like visual stimulus on the stride-to-stride fluctuations of older adults during overground walking. Additionally, …

Aging, Gait Variability, And Adaptability, Collin Douglas Bowersock

Health Services Research Dissertations

The purpose of this work was to study the relationships between age, measures of gait variability, and locomotor adaptability. Measures of gait variability are used to identify maladapted locomotor behavior, motor disease, and risk of falls. The first aim was to determine the relationships between age and measures of gait variability. Thirty-four participants (23-71 years old) walked on a treadmill for 6 minutes at their preferred speed. Variability of stride times and lengths was computed via linear measures (standard deviation and coefficient of variation) and nonlinear measures (sample entropy and detrended fluctuation analysis). Movement trajectory variability of the dominant knee …

Eye Movements And Attention Are Related To Impaired Hand Motor Control In Older Adults, Brittany Heintz Walters

Theses and Dissertations

Visual information is critical for many goal-directed movements and changes in visual information influence hand motor performance in older adults. Knowledge of eye movements during hand motor tasks would provide greater insight into impaired hand function in older adults. This dissertation examined age-related changes in eye movements and the association with hand motor impairments in older adults. Given that attention plays a role in motor performance and declines with age, the relationship between attentional processes and hand motor control was also assessed. A total of 23 young (age 20 – 38) and 28 older (age 65 – 90) adults were …

Assessing The Temporal Organization Of Walking Variability: A Systematic Review And Consensus Guidelines On Detrended Fluctuation Analysis, Deepak K. Ravi, Vivien Marmelat, William R. Taylor, Karl M. Newell, Nicholas Stergiou, Navrag B. Singh

Journal Articles

Human physiological signals are inherently rhythmic and have a hallmark feature in that even distant intrasignal measurements are related to each other. This relationship is termed long-range correlation and has been recognized as an indicator of the optimal state of the observed physiological systems, among which the locomotor system. Loss of long-range correlations has been found as a result of aging as well as disease, which can be evaluated with detrended fluctuation analysis (DFA). Recently, DFA and the scaling exponent α have been employed for understanding the degeneration of temporal regulation of human walking biorhythms in, for example, Parkinson disease …

Early And Late Rapid Torque Characteristics And Select Physiological Correlates In Middle-Aged And Older Males, Alex A. Olmos, Matthew T. Stratton, Phuong L. Ha, Benjamin E. Dalton, Trisha Vandusseldorp, Gerald Mangine, Yuri Feito, Micah J. Poisal, Joshua A. Jones, Tyler M. Smith, Garrett Hester

Faculty and Research Publications

Purpose

The purpose of this study was to compare early and late rapid torque parameters of the plantar flexors (PFs) in middle-aged (MM) and older (OM) males, and determine the effect of normalization to peak torque (PT) and muscle cross-sectional area (CSA).

Methods

Twenty-nine healthy, MM (n = 14; 45 ± 2 yrs) and OM (n = 15; 65 ± 3 yrs) performed rapid, maximal isometric contractions of the PFs. PT, as well as rate of torque development and impulse during the early (0–50 ms; RTD_0-50, IMP_0-50) and late (100–200 ms; RTD_100-200, IMP_{100-200 …}

Bioenergetic Mechanisms Of Age-Related Differences In Muscle Fatigue, Liam F. Fitzgerald

Doctoral Dissertations

Muscle fatigue is defined as the reduced capacity to produce torque or power in response to contractile activity. Previous work has observed greater fatigue in older than young adults in response to high-velocity contractions, but similar fatigue with age in response to moderate-velocity contractions. The mechanisms for these age-related differences is not clear. One potential explanation is a greater accumulation of putative agents of fatigue (e.g., Pi, H₂PO₄^-, and H⁺) in older than young muscle during high- but not moderate-velocity contractions. Older muscle may accumulate these metabolites to greater extent because of deficits …

Insights On Ten Weeks Of Classical Ballet Training And Postural Stability In Older Adults, Hannah Weighart, Sarah Dipasquale

International Journal of Exercise Science

International Journal of Exercise Science 13(1): 101-112, 2020. Older adults show an increased risk of falling as they age, but dance interventions of various genres have been shown to improve postural stability in this population. The purpose of this study was to investigate the effects of a ten-week beginning ballet intervention on postural stability for older adults. Eleven participants enrolled in the Dance Group (DG; 73.3 ± 10.6 years) while six enrolled in the Control Group (CG; 69.5 ± 11.9 years) via convenience sample. Following the intervention, no significant differences were seen within the DG from pre- to post-testing or …

Biomechanics In The 4haie Study: Air Pollution And Musculoskeletal Health - An Update, Daniel Jandacka, Jaroslav Uchityil, David Zahradník, Roman Farana, Dominik Villimek, Jiri Skypala, Jan Urbaczka, Jan Plesek, Adam Motyka, Denisa Blaschova, Gabriela Beinhauerova, Marketa Rygelová, Pavel Brtva, Zuzana Golembiovska, Klara Balazova, Jan Malus, Veronika Horka, Julia F. Silvernail, Gareth Irwin, Miika T. Nieminen, Victor Casula, Vlado Juras, Milos Golian, Steriani Elavsky, Lenka Knapova, Radim Sram, Joseph Hamill

Kinesiology and Nutrition Sciences Faculty Publications

The overall purpose of the 4HAIE study was to assess the influence of the interaction between air pollution and biomechanical, physiological and psychosocial factors on the incidence of injuries, health and well-being. A total of 1,500 active runners and inactive controls aged 18-65 will be recruited. Herein, we describe the biomechanical study design with data examples to investigate musculoskeletal and neuro-mechanics health in different air quality regions.

Serum Myostatin And Igf-1 As Biomarkers Of Sarcopenia: A Proof-Of-Concept Design, Ashley Binns

Graduate Theses and Dissertations

The population comprising older adults is growing exponentially, as are healthcare related costs. Nearly $20 billion is annually expensed by older adults for health-related issues affiliated with age-related decline in skeletal muscle mass. Yet, diagnostic criteria are not readily utilized in clinical practice. PURPOSE: Therefore, the purpose of this study was to provide evidence for use of blood biomarkers (myostatin, IGF-1) to predict appendicular skeletal muscle mass (ASM) among middle-aged and older adults. METHODS: A cross-sectional study was conducted among 106 individuals (n = 68 females; n = 38 males) aged ≥ 40 years of age (60.1 ± 11.1 y) …

Metformin Blunts Muscle Hypertrophy In Response To Progressive Resistance Exercise Training In Older Adults: A Randomized, Double‐Blind, Placebo‐Controlled, Multicenter Trial: The Masters Trial, R. Grace Walton, Cory M. Dungan, Douglas E. Long, S. Craig Tuggle, Kate Kosmac, Bailey D. Peck, Heather M. Bush, Alejandro G. Villasante Tezanos, Gerald Mcgwin, Samuel T. Windham, Fernando Ovalle, Marcas M. Bamman, Philip A. Kern, Charlotte A. Peterson

Center for Muscle Biology Faculty Publications

Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would augment the muscle response to PRT in healthy women and men aged 65 and older. In a randomized, double-blind trial, participants received 1,700 mg/day metformin (N = 46) or placebo (N = 48) throughout the study, and all subjects performed 14 weeks of supervised PRT. Although responses to PRT varied, placebo gained more lean body …