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Osteoblast Activity Is Diminished In Young Spontaneously Hypertensive Rats, Tyler J. Benson, Brandon Cherry, Steve Mifflin, Rhonda Prisby
Osteoblast Activity Is Diminished In Young Spontaneously Hypertensive Rats, Tyler J. Benson, Brandon Cherry, Steve Mifflin, Rhonda Prisby
International Journal of Exercise Science: Conference Proceedings
Spontaneously Hypertensive Rats (SHR) are used as a genetic model of essential hypertension. Reductions in cortical and cancellous bone mass and increased bone turnover have been observed in aged SHR vs. Wistar-Kyoto (WKY) rats, normotensive genetics controls. In addition, antihypertensive aids have been effective in improving bone parameters in hypertensive rats. Thus, the relation between hypertension and bone remodeling warrants further attention. The purpose of this study was to determine how acute (i.e., 9 weeks) hypertension effects bone remodeling parameters (i.e., osteoclast and osteoblast activity). Methods: Right femora from 14-week-old SHR (n=5) and WKY (n=4) rats were dissected, fixed in …