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Estimates Of Persistent Inward Current Decline In Human Soleus Motor Units During Fatigue, Kirby Mendes

Theses and Dissertations (Comprehensive)

Fatigue is defined as any exercise induced reduction in strength or power, and can be attributed to central and peripheral components. Many central and peripheral mechanisms have been extensively studied, but few studies have looked at the changes in the intrinsic properties of motor neurons and their contribution to fatigue. Persistent inward current (PIC) is an important intrinsic property of motor neurons responsible for setting a large increase in the gain of motor output and may contribute to fatigue. Inhibitory inputs such as reciprocal inhibition (RI) have been shown to turn off PICs and reducing the gain of output. PIC …