Life Sciences Commons^™

The Pre-Application Of Hydrocortisone Cream And Its Effect On Transdermal Drug Delivery By Phonophoresis, Patrick Thomas Webb

Theses and Dissertations

Context: Transdermal delivery of hydrocortisone by phonophoresis is used for the treatment of musculoskeletal conditions. Research shows hydrocortisone and other white or opaque topical preparations transmit ultrasound energy poorly. Effective transmission of ultrasound is important in phonophoresis. Main Outcome measured: Samples of subcutaneous interstitial fluid were collected during and for 20 minutes following phonophoresis treatment. Cortisol concentrations were analyzed by an enzyme linked immune-assay (ELISA) test. Objective: Determine the subcutaneous cortisol concentration after two different phonophoresis treatments using a 2.5% hydrocortisone preparation. Design: Randomized design in which 22 healthy participants were assigned to receive a phonophoresis treatment where: 1) hydrocortisone …

Mtor Pathway Activation Following Sciatic Stimulation In Wild-Type And Desmin Knockout Mice, Daniel S. Nelson

Theses and Dissertations

The 52 kDa intermediate filament protein desmin plays an important role in force transmission in skeletal muscle by connecting myofibrils at Z-lines and to the sarcolemma. Desmin content in muscle adapts to contractile activity and may be involved in cellular signaling mechanisms responsible for muscle growth. Purpose: To compare signaling responses of the mTOR pathway in wild type (WT) vs desmin knock out (KO) mice. Methods: WT (n=12) and KO (n=12) mice were exposed to high frequency electric stimulation of the left hindlimb to elicit an acute response of the mTOR pathway. Non-stimulated right hindlimbs were used as a within …

Psychological Well-Being And Dietary Quality Of College Women: Examining The Confounding Influence Of Sleep And Physical Activity, Whitney Ann Hebbert

Theses and Dissertations

Objective. To determine the relationship between overall psychological well-being and stress on diet quality among young adult women and to examine the potential confounding influence of season, physical activity and sleep on these relationships. Design/Participants. The study used a cross-sectional design. Three hundred and fifty-one women were recruited to participate in the study. All participants were university students (20.2 ± 1.6 y). Overall psychological well-being was assessed using the General Well-being Schedule (GWB) and the Perceived Stress Scale (PSS). Diet intake was measured using three 24-hour recalls over a seven day period. The Healthy Eating Index (HEI) was calculated to …

Validation Of Hand-Held Bioelectrical Impedance Analysis For The Assessment Of Body Fat In Young And Old Adults, Lynn A. Wheeler

Theses and Dissertations

Because of health concerns surrounding overweight and obesity, many individuals, health clubs, and physicians have begun using portable measures of body fat (BF) that are inexpensive and easy-to-use. Based on measures from these devices, health-related decisions are made and progress during fitness and/or dietary programs is tracked. However, accuracy of portable BF devices can be questionable, especially in free-living settings. Purpose: The purpose of this study is to evaluate the validity and reliability of a commercially-available, hand-held bioelectrical impedance analysis (BIA) device as a measure of BF during a controlled laboratory condition and a free-living condition. Methods: A total of …

Neural Responses To Food Pictures And Their Association With Dietary Intake, Edward Christenson

Theses and Dissertations

BACKGROUND: Food-related visual cues may affect eating behavior and energy intake. The purpose of this study was to determine the neural response to pictures of food and whether or not the neural responses were associated with energy intake. METHODS: Using a cross-sectional design, 60 adults participated in this study. Each participant reported to the laboratory in a fasted state, were fitted with a 128-electrode electroencephalogram (EEG) net, and were shown pictures grouped into three categories: high-calorie foods, low-calorie foods, and distractor pictures. These pictures were shown in random order. Furthermore, participants were shown these pictures in one passive condition and …

The Relationship Between Sleep Deprivation, Food Motivation, And Energy Intake In Normal-Weight And Obese Females, Lora Light Romney

Theses and Dissertations

Objective: Sleep deprivation has been proposed as a potential correlate of obesity, particularly influencing energy intake. Therefore, the purpose of this study was to compare neural indices of attention related to food motivation and energy intake in normal-weight and obese women under two separate sleep conditions: 1) sleep-restricted (<5 hours) and 2) recommended sleep (~8 hours). This study used a combined cross-over and ex post facto design with condition order counter-balanced. Methods: Twenty-two normal-weight (age=30.9±9.5y, BMI=22.0±1.6 kg/m2) and 18 obese (age=29.7±10.7 y, BMI=36.4±5.3 kg/m2) women completed both sleep conditions. To confirm sleep levels, participants recorded sleep quality and quantity via sleep logs and wore a wrist actigraph. Following each condition, participants reported to the laboratory under the same fed state (energy shake ~10% of total daily needs) to verify they followed the sleep protocol. Subsequently, motivation for food was tested using electroencephalogram (EEG); participants completed a computerized passive-viewing task of food and flowers, while event-related brain potentials (ERPs) were recorded. After EEG testing, participants continued their normal routine but recorded all energy intake using weighed food scales. There were no instructions or limitations on dietary intake. Analyses included P300 and LPP amplitudes in response to picture type, total next day energy intake, and energy intake by several periods of the day. Results: Participants averaged 4.7±0.4 hours of sleep during the sleep-restricted condition and 7.7±0.3 hours during the recommended sleep condition (F=1057.02; P<0.0001). There was no group*condition interaction for next day food motivation (P300: F<2.896, P>0.09; LPP: F<2.967, P>0.093). Next day total energy intake also did not differ by group*condition (F=1.81; P=0.187). When participants were pooled, there was no difference in energy intake by sleep condition (F=0.00; P=0.953). However, when participants’ energy intake was analyzed during the lunch period (following testing to 1:30pm) there was a …

Healthy And Unhealthy Diet Intake And Carotid Intima Media Thickness In Older Adults, Kelsey Joelle Da Silva

Theses and Dissertations

Background -- Cardiovascular disease (CVD) is a primary premature killer of adults and risk of CVD has been linked to modifiable risk factors including dietary intake. Many diet assessment tools are costly, time consuming, and complicated. This study investigated the relationship between diet quality and cardiovascular disease risk as indicated by carotid intima-media thickness (cIMT) using a validated, simple, self-administered rapid food screener. Methods -- Participants were 51 male and 33 female older adults with an average age of 67 years. Carotid intima-media thickness was assessed using B-mode high resolution diagnostic ultrasound. Unhealthy and healthy diet intake was assessed using …

Multifidus Muscle Size And Atrophy Among Dancers With And Without Low Back Pain, Alyssa Leann Smyres

Theses and Dissertations

Design: A single-blinded, cross-sectional observational study.

Objectives: Examine muscle cross-sectional area and symmetry of the lumbar multifidus muscle in elite ballroom dancers with and without low back pain (LBP).

Background: The incidence of LBP among elite ballroom dancers is high and at Brigham Young University is 57%. Previous research has linked lumbar multifidus muscle atrophy to low back pain; however this relationship has not been examined in ballroom dancers.

Methods and Measures: Lumbar multifidus cross-sectional area was assessed at rest on the right and left side at levels L1-L5. Thirty-seven subjects (age 24 ± 3.2 years; height, 172.8 ± 11.3 …

The Effects Of Plantar Fasciitis On Multi-Segment Foot Running Gait Kinematics, Robin Lee Bauer

Theses and Dissertations

Plantar fasciitis is a common lower extremity injury caused by mechanical overload that affects 10% of all runners. Despite its commonality, research results investigating the etiology of the condition and the most efficacious treatment have been equivocal. A potential limitation of previous research assessing the mechanical changes associated with plantar fasciitis may be the modeling of the foot as a single segment. To date no study has investigated running kinematics in individuals with plantar fasciitis using a multi-segment foot model. Sonography has also reported plantar fascia thickening and degeneration associated with plantar fasciitis in non-athletic populations; however it has not …

Relationship Between Counter Movement Jump Performance And Extraversion Level, David James Cornell

Theses and Dissertations

Introduction: Sport psychology literature has demonstrated a relationship between personality and physical ability and athletic performance. In general, individuals who exhibit a greater degree of extraversion display a greater physical ability and athletic performance than individuals who exhibit a lower degree of extraversion. The physiology literature has also demonstrated relationships between extraversion level and movement time and electrophysiological mechanisms (i.e., muscle activity) during a fine movement task. However to date, no study has investigated if these physiological relationships manifest themselves during a gross movement task. If a relationship exists, it may provide mechanistic reasoning behind the previously observed relationships between …

Effects Of Physical Exertion And Alignment Alterations On Trans-Tibial Amputee Gait, And Concurrent Validity Of Prosthesis-Integrated Measurement Of Gait Kinetics, Goeran Fiedler

Theses and Dissertations

This study investigated the effects of slight changes in the alignment of the artificial limb of trans-tibial amputees on the walking pattern on the level of forces and moments, particularly when physical exertion levels increase. Two alignment conditions were assessed in ten trans-tibial amputees while walking with low and with "strong" levels of exertion. Two separate data collection methods were utilized simultaneously: a conventional motion analysis, and continuous recordings from prosthesis-integrated force sensors. While the former was used to compare bilateral leg symmetry across conditions, the latter allowed analyzing unilateral step variability within subjects. This paper presents both analyses in …

Development Of A Methodology For The Quantification Of Physiological Load For Soccer Players, Robert W. Wilson

Theses and Dissertations

The overall aim of this research project was to devise valid mathematical models for quantifying the physiological load (PL) of practices and competitions for female and male NCAA Division I collegiate soccer players. Data from sub-maximal and maximal effort tests were used to construct these models. After development of the physiological load quantification (PLQ) models, the validity of them occurred by comparing them to the physiological gold standard of performed work, volume of oxygen consumed (V*O2). Last, comparisons of the scores from the PLQ models to the PL scores from the previous models occurred. In combination these three studies have …

Relationship Between Total Body Mass, Fat-Free Mass, Fat Mass, And Bone Mineral Density Of The Hip In Middle-Age Women: The Roles Of Diet, Physical Activity, And Menopause, Elizabeth Reid Fosson

Theses and Dissertations

Objective: This study was conducted to investigate the relationship between hip bone mineral density (BMD), fat free mass (FFM), fat mass (FM), and total body mass (TBM) and the extent to which these relationships were modified by various confounding factors. The cross-sectional analysis included 262 healthy females (mean age 41.6±3.0 years). Methods: BMD of the hip and body composition were assessed by the Hologic 4500W dual energy x-ray absorptiometry (DXA) system. Total and intensity of physical activity (PA) were objectively measured using an Actigraph accelerometer. Dietary calcium and vitamin D from food and beverages, as well as from supplements, were …

A Comparison Of Two Tape Techniques On Navicular Drop And Center Of Pressure Measurements, Krista M. Prusak

Theses and Dissertations

Introduction: Foot over-pronation, attributable to Tibialis Posterior (TP) muscle weakness, is a possible cause of medial tibial stress syndrome (MTSS)3. Taping may provide a viable alternative for a dysfunctional TP and its associated navicular drop (ND). The most commonly used Augmented LowDye (ALD) technique has shown to prevent ND, but is time- and cost- intensive, leading us to explore an alternative technique. The purpose of this study was to assess the effectiveness of a new, anti-pronation (AP) taping technique, as compared to the ALD, to (a) reduce or prevent ND and (b) cause a lateral shift in the center of …

Effects Of Vibration On Vertical And Joint Stiffness In Ankle Instability And Healthy Subjects, Mark J. Coglianese

Theses and Dissertations

Some have suggested acute increases in musculotendinous stiffness (k) following whole body vibration (WBV). Others propose that chronic ankle instability (CAI) may alter k of the lower extremity. Changes in proprioceptive activity and/or gamma motoneuron activation post-WBV and/or due to CAI could lead to alterations in k. However, little is known about acute effects of WBV on k and less is known about changes in k with CAI. PURPOSE: Assess differences in vertical and joint k between healthy and CAI subjects during single-limb landings and detect alterations in k measures post-vibration. METHODS: Subjects were identified as CAI via the FAAM, …

Estimating Vo2max Using A Personalized Step Test, Catherine Webb

Theses and Dissertations

The purpose of this study was to develop a personalized step test and a valid regression model that used non-exercise data and data collected during the step test to estimate VO2max in males and females 18 to 30 years of age. All participants (N= 80) successfully completed a step test with the starting step rate and step height being determined by the self-reported perceived functional ability (PFA) score and participant's height, respectively. All participants completed a maximal graded exercise test (GXT) to measure VO2max. Multiple linear regression analysis yielded the following equation (R = 0.90, SEE = 3.43 mL/kg/min): 45.938 …

A Multiple-Linear Regression Model To Predict Carotid Artery Imt In A Senior Population Of Competitors At The Huntsman World Senior Games, Cheryl Ann Smith

Theses and Dissertations

Carotid intima-media thickness (cIMT) is a valid measure of cardiovascular disease (CVD). Physical activity appears to improve cIMT, however, research is inconclusive. This study investigated the relationship between physical activity (physical activity rating (PA-R)) and cardiovascular fitness (predicted VO2max , perceived functional ability (PFA)) and cIMT. Data collected from 341 seniors (≥50 years) competing in the Huntsman World Senior Games (HWSG) included blood lipids, inflammatory makers, blood glucose, blood pressure (BP) and anthropometric measurements of obesity and central adiposity. Multiple regression analysis was used to determine correlations of measured variables with cIMT. Two of the fitness related variables, PFA (r …

Intensity Of Physical Activity And Body Composition: A Cross-Sectional Analysis Of Young Adult Women, Pamela Ruth Borup

Theses and Dissertations

Purpose: The purpose of this study was to assess the relationship between intensity of physical activity and body composition in 239 young adult women.

Methods: This study was cross-sectional. Participants were recruited from October 2009 to December 2011 and included women from 36 different states and 6 different countries. Physical activity was objectively measured using accelerometers worn for seven days. Body composition was measured using the BOD POD. Height, weight, and circumferences were assessed.

Results: Participant's mean age was 20.6±1.6 years. Their mean BMI was 22.6±3.0 kg/m2 and mean body fat percentage was 26.4±6.3 %. Average total activity counts per …

Lower Body Kinetics During The Delivery Phase Of The Rotational Shot Put Technique, Jillian Mary Williams

Theses and Dissertations

The purpose of this study was to measure the change in joint energy of the hip,knee and ankle of the right and left leg, in the sagittal plane during the delivery phase of the rotational shot put. We hypothesized that (1) throwers who produced a greater total hip energy change would have greater horizontal displacement and (2) throwers who produced a higher ratio of hip energy, in each leg independently, would produce greater horizontal displacement. Subjects (n = 8) must have been right-handed, collegiate or post collegiate level throwers trained in the rotational technique. Vicon Nexus System (Denver, CO, USA) …

Lower Extremity Joint Moments During The Active Peak Vertical Ground Reaction Force In Three Different Running Conditions, Tyler W. Standifird

Theses and Dissertations

The purpose of this study was to compare joint moments during the active peak vertical ground reaction force (PVGRF) when running in three conditions. Twenty-five subjects, sixteen male and nine female, were measured using 3-dimensional motion analysis while running barefoot, in Vibram FiveFingers® (VF®) minimalist running shoes and in traditional running shoes at a 7-minute-mile pace (3.84 m/s). Joint moment differences were calculated and compared using a mixed model analysis of variance. Results showed the VF® was effective at mimicking both the kinetic and kinematic attributes of barefoot running. The only significant difference found when comparing barefoot and VF® running …