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Pparα L162v Underlies Variation In Serum Triglycerides And Subcutaneous Fat Volume In Young Males, Julieta Uthurralt, Heather Gordish-Dressman, Meg Bradbury, Carolina Tesi-Rocha, Joseph Devaney, Brennan Harmon, Erica K. Reeves, Cinzia Brandoli, Barbara C. Hansen, Richard L. Siep, Paul D. Thompson, Thomas B. Price, Theodore J. Angelopoulos, Priscilla M. Clarkson
Pparα L162v Underlies Variation In Serum Triglycerides And Subcutaneous Fat Volume In Young Males, Julieta Uthurralt, Heather Gordish-Dressman, Meg Bradbury, Carolina Tesi-Rocha, Joseph Devaney, Brennan Harmon, Erica K. Reeves, Cinzia Brandoli, Barbara C. Hansen, Richard L. Siep, Paul D. Thompson, Thomas B. Price, Theodore J. Angelopoulos, Priscilla M. Clarkson
Priscilla M. Clarkson
Background: Of the five sub-phenotypes defining metabolic syndrome, all are known to have strong genetic components (typically 50–80% of population variation). Studies defining genetic predispositions have typically focused on older populations with metabolic syndrome and/or type 2 diabetes. We hypothesized that the study of younger populations would mitigate many confounding variables, and allow us to better define genetic predisposition loci for metabolic syndrome. Methods: We studied 610 young adult volunteers (average age 24 yrs) for metabolic syndrome markers, and volumetric MRI of upper arm muscle, bone, and fat pre- and post-unilateral resistance training. Results: We found the PPARα L162V polymorphism …