Life Sciences Commons^™

The Effect Of Sleep Restriction On Coagulation And Fibrinolysis After Heavy Exercise, Paul A. Roberson

Masters Theses, 2010-2019

Introduction: Research has shown exercise elicits a hemostatic response affecting coagulation and fibrinolysis. Furthermore, prior research has determined circadian fluctuations exist where clotting potential increases in the morning as a result of increased PAI-1 and decreased tPA which is further exacerbated by exercise. These circadian fluctuations and exercise responses have the potential to be accentuated by poor sleep. The purpose of this study is to determine the effects of sleep restriction on tPA activity, PAI-1 activity, and Factor VIII antigen activity (FVIII) while resting and after exercise.

Methods: 7 Subjects underwent two similar exercises sessions (EX). EX1 occurred in the …

Volume Of Physical Activity And Hemostatic Variables In Pregnant Women, Christine Nicewonger

Masters Theses, 2010-2019

Purpose: This study investigated the relationship between blood coagulation and fibrinolytic potential and physical activity. Physical activity levels to predict blood coagulation and fibrinolytic potential were also examined. Methods: Twenty-three pregnant women, aged 19-34 yrs, had a fasted blood draw between 6 and 10 a.m. analyzed for tPA antigen, tPA activity, PAI-1 antigen, and vWF antigen. Trimester specific volume of leisure time physical activity was assessed by the Modifiable Activity Questionnaire (MAQ) and converted to METmin/wk. Based on MAQ results, women were grouped as meeting (“active”) or not meeting (“sedentary”) physical activity recommendations established by American College of Obstetrics and …