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The Influence Of A Cyp1a2 Polymorphism On The Hemostatic Response To Caffeine, Joseph James Aiello

Masters Theses, 2010-2019

Research has continued to provide conflicting results of caffeine’s effect on acute coronary events; although it is now apparent that a single nucleotide polymorphism at intron 1 of the cytochrome P450 (CYP1A2) gene may explain these equivocal findings. Despite the fact that markers of coagulation potential and fibrinolytic potential are associated with risk for myocardial infarction, the extent to which caffeine affects these markers is unknown. The purposes of this study were to determine the acute effects of caffeine on coagulation and fibrinolytic potential at rest and following maximal exercise and to determine if hemostatic responses engendered by caffeine are …