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Fifty Years Of Microneurography: Learning The Language Of The Peripheral Sympathetic Nervous System In Humans, J Kevin Shoemaker, Stephen A. Klassen, Mark B. Badrov, Paul J. Fadel
Fifty Years Of Microneurography: Learning The Language Of The Peripheral Sympathetic Nervous System In Humans, J Kevin Shoemaker, Stephen A. Klassen, Mark B. Badrov, Paul J. Fadel
Kinesiology Publications
As a primary component of homeostasis, the sympathetic nervous system enables rapid adjustments to stress through its ability to communicate messages among organs and cause targeted and graded end organ responses. Key in this communication model is the pattern of neural signals emanating from the central to peripheral components of the sympathetic nervous system. But what is the communication strategy employed in peripheral sympathetic nerve activity (SNA)? Can we develop and interpret the system of coding in SNA that improves our understanding of the neural control of the circulation? In 1968, Hagbarth and Vallbo (Hagbarth KE, Vallbo AB. Acta Physiol …
Methods And Considerations For The Analysis And Standardization Of Assessing Muscle Sympathetic Nerve Activity In Humans., Daniel W White, J Kevin Shoemaker, Peter B Raven
Methods And Considerations For The Analysis And Standardization Of Assessing Muscle Sympathetic Nerve Activity In Humans., Daniel W White, J Kevin Shoemaker, Peter B Raven
Kinesiology Publications
The technique of microneurography and the assessment of muscle sympathetic nerve activity (MSNA) are used in laboratories throughout the world. The variables used to describe MSNA, and the criteria by which these variables are quantified from the integrated neurogram, vary among studies and laboratories and, therefore, can become confusing to those starting to learn the technique. Therefore, the purpose of this educational review is to discuss guidelines and standards for the assessment of sympathetic nervous activity through the collection and analysis of MSNA. This review will reiterate common practices in the collection of MSNA, but will also introduce considerations for …
Sympathetic Neural Recruitment Strategies: Responses To Severe Chemoreflex And Baroreflex Stress, Mark B. Badrov, Charlotte W. Usselman, J Kevin Shoemaker
Sympathetic Neural Recruitment Strategies: Responses To Severe Chemoreflex And Baroreflex Stress, Mark B. Badrov, Charlotte W. Usselman, J Kevin Shoemaker
Kinesiology Publications
This study tested the hypothesis that neural coding patterns exist within the autonomic nervous system. We investigated sympathetic axonal recruitment strategies in humans during chemoreflex- and baroreflex-mediated sympathoexcitation using a novel action potential (AP) analysis technique. Muscle sympathetic nerve activity (microneurography) was collected in 11 young individuals (6 females) during baseline and two subsequent protocols: 1) severe chemoreflex stimulation (maximal end-inspiratory apnea following rebreathe), and 2) severe baroreceptor unloading (−80 mmHg lower body negative pressure; LBNP). When compared with each respective baseline, apnea and LBNP increased AP frequency and mean AP content per sympathetic burst (all P < 0.01). When APs were binned according to peak-to-peak amplitude (i.e., into “clusters”), total clusters detected increased during both apnea (Δ7 ± 5; P …