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Protocol-Dependence Of Middle Cerebral Artery Dilation To Modest Hypercapnia., Baraa K Al-Khazraji, Sagar Buch, Mason Kadem, Brad J Matushewski, Kambiz Norozi, Ravi S Menon, J Kevin Shoemaker Jun 2017

Protocol-Dependence Of Middle Cerebral Artery Dilation To Modest Hypercapnia., Baraa K Al-Khazraji, Sagar Buch, Mason Kadem, Brad J Matushewski, Kambiz Norozi, Ravi S Menon, J Kevin Shoemaker

Kinesiology Publications

There is a need for improved understanding of how different cerebrovascular reactivity (CVR) protocols affect vascular cross-sectional area (CSA) to reduce error in CVR calculations when measures of vascular CSA are not feasible. In human participants, we delivered ∼±4 mm Hg end-tidal partial pressure of CO2 (PETCO2) relative to baseline through controlled delivery, and measured changes in middle cerebral artery (MCA) CSA (7 Tesla magnetic resonance imaging (MRI)), blood velocity (transcranial Doppler and Phase contrast MRI), and calculated CVR based on a 3-minute steady-state (+4 mm Hg PETCO2) and a ramp (-3 to +4 mm Hg of PETCO2). We observed …


Impact Of Age On Cerebrovascular Dilation Versus Reactivity To Hypercapnia., Nicole S Coverdale, Mark B Badrov, J Kevin Shoemaker Jan 2017

Impact Of Age On Cerebrovascular Dilation Versus Reactivity To Hypercapnia., Nicole S Coverdale, Mark B Badrov, J Kevin Shoemaker

Kinesiology Publications

This study quantified the effect of age on cerebrovascular reactivity and cerebrovascular conductance while accounting for differences in grey matter volume in younger (YA: n = 12; 24 ± 4 years, six females) and older adults (OA: n = 10; 66 ± 7 years; five females). Cerebral blood flow velocity (CBFV; transcranial Doppler) in the middle cerebral artery (MCA), MCA cross-sectional area (CSA), intracranial volumes (magnetic resonance imaging), and mean arterial pressure (MAP; Finometer), were measured under normocapnic and hypercapnic (6% carbon dioxide) conditions. Cerebral blood flow (CBF) was quantified from CBFV and MCA CSA and normalized to grey matter …