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Critical Analysis Of Cerebrovascular Autoregulation During Repeated Head-Up Tilt., R L Hughson, M R Edwards, D D O'Leary, J K Shoemaker
Critical Analysis Of Cerebrovascular Autoregulation During Repeated Head-Up Tilt., R L Hughson, M R Edwards, D D O'Leary, J K Shoemaker
Kinesiology Publications
BACKGROUND AND PURPOSE: Cerebrovascular autoregulation has been described with a phase lead of cerebral blood flow preceding changes in cerebral perfusion pressure (CPP), but there has been less focus on the effect of CPP on cerebral vascular resistance. We investigated these relations during spontaneous fluctuations (control) and repeated head-up tilt.
METHODS: Eight healthy adults were studied in supine rest and repeated tilt with 10-second supine, 10 seconds at 45 degrees head-up tilt for a total of 12 cycles. Cerebral blood flow was estimated from mean flow velocity (MFV) by transcranial Doppler ultrasound, CPP was estimated from corrected finger pressure (CPP(F)), …