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- Cachexia (2)
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- Neck Circumference (1)
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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Role Of Sex Differences On Cancer Cachexia Progression And Fibrosis During Cancer Cachexia Development, Wesley Haynie
Role Of Sex Differences On Cancer Cachexia Progression And Fibrosis During Cancer Cachexia Development, Wesley Haynie
Graduate Theses and Dissertations
Cancer cachexia is a multifactorial wasting syndrome characterized by losses in bodymass >5% and occurs in approximately 80% of all cancer patients. Chronic inflammation and fibrosis play roles in cancer cachexia and a greater understanding of these contributing pathways to this pathology will pave the way for potential therapeutic avenues. While inflammation and fibrosis have been researched in various models of cancer cachexia, little to no studies have been performed in both sexes as most previous studies focus on males. PURPOSE The purpose of these studies is to investigate the role of fibrosis on cancer cachexia development as well as …
A Time-Course Characterization Of Muscle Function And Mitochondrial Markers During Colorectal Cancer-Induced Cachexia In Tumor-Bearing Male Mice, Ana Cabrera Ayuso
A Time-Course Characterization Of Muscle Function And Mitochondrial Markers During Colorectal Cancer-Induced Cachexia In Tumor-Bearing Male Mice, Ana Cabrera Ayuso
Graduate Theses and Dissertations
Cachexia is a multisystemic and multifactorial syndrome prevalent in cancer patients. It is clinically defined by involuntary loss of >5% weight in a six-month window, despite nutritional interventions. A negative energy balance characterizes cancer cachexia (CC), it is associated with weakness and fatigue in skeletal muscle. Impaired muscle function is associated with lower quality of life in cancer patients. Defects in mitochondrial function are strongly associated with muscle wasting. This study explored muscular contractile function and mitochondrial quality control (MQC) markers in soleus, gastrocnemius, and tibialis anterior (TA) muscles of C26-induced male tumor-bearing mice during a 25-day time course. It …
A Radiographic Investigation Of Anthropometrics, Neck Posture, And Neck Strength In Individuals With Enlarged External Occipital Protuberances, Caleb Burruss
Graduate Theses and Dissertations
Overview: Enlarged external occipital protuberances (EEOPs) are found in 41% of young adults. These EEOPs have the potential to lead to pain throughout life and possibly surgery. Little is known of the pathophysiology or characteristics that could lead to these EEOPs. Purpose: The purpose of this study is to use radiographic measurements to investigate how anthropometrics, neck posture and neck strength in flexion and extension differ between those with and without an EEOP. Methods: 80 radiographs from three different studies were digitized and the marking of landmarks performed in ImageJ. The cut-off for an EEOP was established as any EOP …
Classroom Physical Activity Breaks Effect On Executive Function And Academic Achievement In Elementary School Students, Mark A. Bjornsen
Classroom Physical Activity Breaks Effect On Executive Function And Academic Achievement In Elementary School Students, Mark A. Bjornsen
Graduate Theses and Dissertations
Objectives: There were three aims in conducting this pilot study. First, determine the Plus Minus Task assessment's reliability to measure the executive function of shifting. Second, determine the feasibility and acceptability of CPAB by students and teachers. Finally, determine the preliminary dose-response of acute physical activity on shifting in elementary students. Methods: This was a pilot study of a classroom physical activity break intervention. Utilizing a withinsubject, cross-over design, students participated in a practice day and then all three treatment conditions: a 10-minute seated lesson (control condition) and 5 and 10 minutes (experimental conditions) of classroom physical activity breaks. A …
Narrative Inquiry: Life Experiences Of Elite Athletes, Sarah Elizabeth Brown
Narrative Inquiry: Life Experiences Of Elite Athletes, Sarah Elizabeth Brown
Graduate Theses and Dissertations
Elite athletes face numerous personal and professional pressures and high-stress experiences; however, there is a gap in the literature connecting identity development with these life experiences. Using narrative inquiry analysis with six emerging adult athletes competing at professional and Olympic levels, this study identified self-narratives they created from life experiences within the context of sport and analyzed when these meanings were formed. Athletes described experiences causing great psychological disturbances as a normal risk within their sport and needing to regulate or compartmentalize their emotions to get through those experiences. Participants discussed various roles they play within their team but lacked …
Sex-Based Differences In Acvr2b And Grb10 Expression In Skeletal Muscle During Induced Cancer Cachexia And Disuse, Lauren Martinez
Sex-Based Differences In Acvr2b And Grb10 Expression In Skeletal Muscle During Induced Cancer Cachexia And Disuse, Lauren Martinez
Graduate Theses and Dissertations
Background: Muscle atrophy is the shrinkage of muscle fibers that are largely maintained by a balance of protein synthesis and degradation. Imbalances in protein synthesis and degradation are observed in different muscle atrophy disorders such as cancer cachexia and disuse. These forms of muscle atrophy produce distinct wasting pathologies that are influenced by biological sex. Activin receptor type-2B (ACVR2B) and Growth factor receptor-bound protein 10 (GRB10) have been identified as genes that potentially regulate muscle mass while also displaying sexually dimorphic differences. Purpose: To examine the influence of ACVR2B and GRB10 throughout the development of cancer cachexia and disuse-induced atrophy …