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Full-Text Articles in Life Sciences

Cardiovascular Disease Risk And Menopause: Effects Of Cardiorespiratory Fitness, Exercise, And Follicle Stimulating Hormone, Corinna Serviente Nov 2018

Cardiovascular Disease Risk And Menopause: Effects Of Cardiorespiratory Fitness, Exercise, And Follicle Stimulating Hormone, Corinna Serviente

Doctoral Dissertations

Menopause is associated with adverse changes in cardiovascular disease risk factors. A reduction in estrogens is most commonly associated with changing cardiovascular disease risk; however, recent observations suggest that the increase in follicle stimulating hormone that accompanies menopause may also influence risk, potentially through its influence on lipid levels. The changes in cardiovascular disease risk factors may adversely affect endothelial cell function, a pre-clinical marker for cardiovascular disease. Whether cardiorespiratory fitness is protective of endothelial health in this population, thereby mitigating the changes in risk that accompany menopause, is unclear. This dissertation evaluated differences in endothelial health and endothelial responses …


Feasibiity And Efficacy Of A Movement-Training Program On Physical Fitness, Fundamental Movement Skills, And Physical Activity In Third And Fourth Grade Students, Brittany Masteller Oct 2018

Feasibiity And Efficacy Of A Movement-Training Program On Physical Fitness, Fundamental Movement Skills, And Physical Activity In Third And Fourth Grade Students, Brittany Masteller

Doctoral Dissertations

Recent initiatives have focused on exploring the relationship between fitness, fundamental movement skills, psychosocial mediators, and physical activity in children to help design better interventions to improve these behaviors. FUNdamental Integrative Training (FIT) is an approach to physical education that uses age-appropriate exercises to improve physical fitness in youth, with the longer-term goal to physically prepare children for an active lifestyle beyond childhood. We evaluated the feasibility and efficacy of a 12-week, FIT program on physical fitness, fundamental movement skills, psychosocial mediators (self-efficacy, enjoyment and social support), and physical activity, among third and fourth grade students. Seven classrooms in one …


Observing The Molecular Basis Of Thin Filament Activation With A Three Bead Laser Trap Assay, Thomas Longyear Mar 2018

Observing The Molecular Basis Of Thin Filament Activation With A Three Bead Laser Trap Assay, Thomas Longyear

Doctoral Dissertations

Muscle contracts after calcium (Ca++) is released into the muscle cell, resulting from a cascade of events which result in myosin, the molecular motor of muscle, to produce force and motion. Myosin cyclically binds to a regulated thin filament, using the chemical energy of ATP to produce force and motion. Perturbations in muscle, such as a build-up of metabolic by-products or point mutations in key contractile proteins, can inhibit these functions in both skeletal and cardiac muscle either acutely or chronically. Despite the many years we have studied skeletal and cardiac muscle, we still do not have a clear picture …