Life Sciences Commons^™

Metformin Alleviates Hepatic Iron Overload And Ferroptosis Through Ampk-Ferroportin Pathway In Hfd-Induced Nafld, Fangzhi Yue, Ying Shi, Shanyu Wu, Lin Xing, Dan He, Lin Wei, Anqi Qiu, Ryan D. Russell, Dongmei Zhang

Health & Human Performance Faculty Publications and Presentations

Highlights

• Metformin alleviates HIO and ferroptosis in HFD-induced NAFLD

• FPN is involved in the molecular mechanism of metformin on HIO in HFD-induced NAFLD

• Metformin upregulates FPN expression by reducing lysosomal ubiquitination degradation

Summary

Metformin prevents progression of non-alcoholic fatty liver disease (NAFLD). However, the potential mechanism is not entirely understood. Ferroptosis, a recently recognized nonapoptotic form of regulated cell death, has been reported to be involved in the pathogenesis of NAFLD. Here, we investigated the effects of metformin on ferroptosis and its potential mechanism in NAFLD. We found that metformin prevented the progression of NAFLD, and alleviated hepatic iron …

Hemodynamics And Arterial Stiffness In Response To Oral Glucose Loading In Individuals With Type Ii Diabetes And Controlled Hypertension, Yu Lun Tai, Smaran Marupudi, Gabriel A. Figueroa, Ryan D. Russell

Health & Human Performance Faculty Publications and Presentations

Introduction: Type 2 diabetes (T2D), the fastest growing pandemic, is typically accompanied by vascular complications. A central hallmark of both T2D and vascular disease is insulin resistance which causes impaired glucose transport and vasoconstriction concomitantly. Those with cardiometabolic disease display greater variation in central hemodynamics and arterial elasticity, both potent predictors of cardiovascular morbidity and mortality, which may be exacerbated by concomitant hyperglycemia and hyperinsulinemia during glucose testing. Thus, elucidating central and arterial responses to glucose testing in those with T2D may identify acute vascular pathophysiologies triggered by oral glucose loading.

Aim: This study compared hemodynamics and arterial stiffness to …

Acute And Chronic Bone Marker And Endocrine Responses To Resistance Exercise With And Without Blood Flow Restriction In Young Men, Debra A. Bemben, Vanessa D. Sherk, Samuel R. Buchanan, Sojung Kim, Kyle Sherk, Michael G. Bemben

Health & Human Performance Faculty Publications and Presentations

In this study, we compared acute and chronic bone marker and hormone responses to 6 weeks of low intensity (20% 1RM) blood flow restriction (BFR20) resistance training to high intensity (70% 1RM) traditional resistance training (TR70) and moderate intensity (45% 1RM) traditional resistance training (TR45) in young men (18–35 years). Participants were randomized to one of the training groups or to a control group (CON). The following training programs were performed 3 days per week for 6 weeks for knee extension and knee flexion exercises: BFR20, 20%1RM, 4 sets (30, 15, 15, 15 reps) wearing blood flow restriction cuffs around …

Bone, Biomarker, Body Composition, And Performance Responses To 8 Weeks Of Reserve Officers' Training Corps Training, Breanne S. Baker, Samuel R. Buchanan, Christopher D. Black, Michael G. Bemben, Debra A. Bemben

Health & Human Performance Faculty Publications and Presentations

Context: Military personnel engage in vigorous exercise, often resulting in higher bone mineral density; however, leg bone injuries occur frequently in this population. Predictors of change in tibial bone quality and strength need to be characterized in this high-risk population.

Objectives: To examine the effects of an 8-week military training intervention on total body and site-specific bone density and tibial bone quality, serum biomarkers (parathyroid hormone and sclerostin), body composition, and physical performance and to investigate which outcome variables (biomarkers, body composition, and physical performance) predict estimated tibial bone strength in college-aged Reserve Officers' Training Corps (ROTC) participants.

Design: Prospective …

Muscle Performance Changes With Age In Active Women, Ryan M. Miller, Eduardo D. S. Freitas, Aaron D. Heishman, Keldon M. Peak, Samuel R. Buchanan, J. Mikhail Kellawan, Hugo M. Pereira, Debra A. Bemben, Michael G. Bemben

Health & Human Performance Faculty Publications and Presentations

The purpose of this study was to examine age-related differences in muscle performance in women divided into young (YW, 20–39 years, n = 29) middle-aged (MAW, 40–59 years, n = 33), and older (OW, ≥60 years, n = 40) age groups. Methods: Hand grip strength, vertical jump performance, and knee extensor (KE) strength (0 deg/s, 60 deg/s, and 240 deg/s), speed of movement (SoM; at 1 Nm, 20%, 40%, and 60% isometric strength), and endurance (30-repetition test at 60 degs/s and 240 deg/s) were assessed. Computed tomography-acquired muscle cross-sectional area (mCSA) was measured and included to determine specific strength (KE …

Nox2 Inhibition Regulates Stress Response And Mitigates Skeletal Muscle Fiber Atrophy During Simulated Microgravity, John M. Lawler, Jeffrey M. Hord, Pat Ryan, Dylan Holly, Mariana Janini Gomes, Dinah Rodriguez, Vinicius Guzzoni

Health & Human Performance Faculty Publications and Presentations

Insufficient stress response and elevated oxidative stress can contribute to skeletal muscle atrophy during mechanical unloading (e.g., spaceflight and bedrest). Perturbations in heat shock proteins (e.g., HSP70), antioxidant enzymes, and sarcolemmal neuronal nitric oxidase synthase (nNOS) have been linked to unloading-induced atrophy. We recently discovered that the sarcolemmal NADPH oxidase-2 complex (Nox2) is elevated during unloading, downstream of angiotensin II receptor 1, and concomitant with atrophy. Here, we hypothesized that peptidyl inhibition of Nox2 would attenuate disruption of HSP70, MnSOD, and sarcolemmal nNOS during unloading, and thus muscle fiber atrophy. F344 rats were divided into control (CON), hindlimb unloaded (HU), …

Vascular Responses To High-Intensity Battling Rope Exercise Between The Sexes, Erica M. Marshall, Jason C. Parks, Tyler J. Singer, Yu Lun Tai, Alexa R. Debord, Stacie M. Humm, J. Derek Kingsley

Health & Human Performance Faculty Publications and Presentations

The purpose of the study was to assess high-intensity battling rope exercise (HI-BRE) on hemodynamics, pulse wave reflection and arterial stiffness during recovery and between sexes. Twenty-three young, healthy resistance-trained individuals (men: n = 13; women: n = 10) were assessed for all measures at Rest, as well as 10-, 30-, and 60-minutes following HI-BRE. A one-way repeated measures ANOVA was used to analyze the effects of HI-BRE across time (Rest, 10, 30, and 60-minutes) on all dependent variables. Significant main effects were analyzed using paired t-tests with a Sidak correction factor. Significance was accepted a priori at p 0.05. …

Effect Of Additional Weight On Human Squat Exercise Stability: Ground Reaction Forces And Centers Of Pressure, Jose Galarza, Dumitru Carantu

Mechanical Engineering Faculty Publications and Presentations

The main focus of this work is to investigate the effect of weight on the stability of human squat exercise. The squat exercise is a common daily activity. Experiments are conducted using one human subject. A VICON motion analysis system integrated with Force Plates is utilized for these experiments. An experimental protocol is developed and followed. This work analyzes the time series of the normal component of the ground reaction forces and each coordinate of the center of pressure. These time series are used to estimate the Lyapunov Exponents using Rosenstein method. MATLAB software package is used for this investigation. …

The Effects Of Machine-Weight And Free-Weight Resistance Exercise On Hemodynamics And Vascular Function, Erica M. Marshall, Jason C. Parks, Yu Lun Tai, J. Derek Kingsley

Health & Human Performance Faculty Publications and Presentations

The purpose of this study was to examine hemodynamic and vascular responses between machine-weight and free-weight exercise. Resistance-trained individuals were assigned to a machine-weight (n = 13) or free-weight (n = 15) group. Groups completed two visits consisting of their assigned exercise condition and a control (CON). A 2 × 2 × 3 repeated measures ANOVA was used to test the effects of group across condition and time on the hemodynamic parameters [cardiac output (CO), heart rate (HR), total peripheral resistance (TPR), mean arterial pressure (MAP), and stroke volume (SV)]. A 2 × 2 × 2 repeated measures …

Postprandial Microvascular Blood Flow In Skeletal Muscle: Similarities And Disparities To The Hyperinsulinaemic-Euglycaemic Clamp, Katherine M. Roberts-Thomson, Andrew C. Betik, Dino Premilovac, Stephen Rattigan, Stephen M. Richards, Renee M. Ross, Ryan D. Russell, Gunveen Kaur, Lewan Parker, Michelle A. Keske

Health & Human Performance Faculty Publications and Presentations

Skeletal muscle contributes to ~40% of total body mass and has numerous important mechanical and metabolic roles in the body. Skeletal muscle is a major site for glucose disposal following a meal. Consequently, skeletal muscle plays an important role in postprandial blood glucose homeostasis. Over the past number of decades, research has demonstrated that insulin has an important role in vasodilating the vasculature in skeletal muscle in response to an insulin infusion (hyperinsulinaemic-euglycaemic clamp) or following the ingestion of a meal. This vascular action of insulin is pivotal for glucose disposal in skeletal muscle, as insulin-stimulated vasodilation increases the delivery …

Weight Loss And Weight Gain Among Participants In A Community-Based Weight Loss Challenge, Merrill D. Funk, Minjae Lee, Michelle L. Vidoni, Belinda M. Reininger

Health & Human Performance Faculty Publications and Presentations

Background

To describe the characteristics of participants who registered for multiple annual offerings of a community-based weight loss program called The Challenge, and to determine participant characteristics associated with weight change over multiple offerings of The Challenge occurring during the years 2010–2016.

Methods

Multivariable linear mixed effects analyses were conducted to describe percent weight change within and between offerings of The Challenge by participant characteristics.

Results

There were 669 and 575 participants included in the within and between analyses, respectively, for offerings of The Challenge. Among the 434 participants who lost weight in their first attempt at The Challenge and …

Are The Metabolic Benefits Of Resistance Training In Type 2 Diabetes Linked To Improvements In Adipose Tissue Microvascular Blood Flow?, Donghua Hu, Ryan D. Russell, Devika Remash, Timothy Greenaway, Stephen Rattigan, Kathryn A. Squibb, Graeme Jones, Renee M. Ross, Christian K. Roberts, Dino Premilovac

Health & Human Performance Faculty Publications and Presentations

The microcirculation in adipose tissue is markedly impaired in type 2 diabetes (T2D). Resistance training (RT) often increases muscle mass and promotes a favorable metabolic profile in people with T2D, even in the absence of fat loss. Whether the metabolic benefits of RT in T2D are linked to improvements in adipose tissue microvascular blood flow is unknown. Eighteen sedentary people with T2D (7 women/11 men, 52 ± 7 yr) completed 6 wk of RT. Before and after RT, overnight-fasted participants had blood sampled for clinical chemistries (glucose, insulin, lipids, HbA1c, and proinflammatory markers) and underwent an oral glucose challenge (OGC; …

Changes In Endothelial Function After Acute Resistance Exercise Using Free Weights, Yu Lun Tai, Erica M. Marshall, Jason C. Parks, Xian Mayo, Alaina Glasgow, J. Derek Kingsley

Health & Human Performance Faculty Publications and Presentations

We determined the effects of an acute bout of free-weight resistance exercise (ARE) on cardiovascular hemodynamics and endothelial function in resistance-trained individuals. Nineteen young, healthy, resistance-trained individuals performed two randomized sessions consisting of ARE or a quiet control (CON). The ARE consisted of three sets of 10 repetitions at 75% 1-repetition maximum for the squat, bench press, and deadlift. Cardiovascular hemodynamics was assessed using finger photoplethysmography. Forearm blood flow (FBF), and vasodilatory capacity markers, were assessed using venous occlusion plethysmography. Forearm vascular conductance was calculated by the division of mean FBF by mean arterial pressure. A two-way ANOVA was used …

Validity Of Wrist-Worn Consumer Products To Measure Heart Rate And Energy Expenditure, R. S. Thiebaud, Merrill D. Funk, Jacelyn C. Patton, Brook L. Massey, Terri E. Shay, Martin G. Schmidt, Nicolas Giovannitti

Health & Human Performance Faculty Publications and Presentations

Introduction: The ability to monitor physical activity throughout the day and during various activities continues to improve with the development of wrist-worn monitors. However, the accuracy of wrist-worn monitors to measure both heart rate and energy expenditure during physical activity is still unclear. The purpose of this study was to determine the accuracy of several popular wrist-worn monitors at measuring heart rate and energy expenditure.

Methods: Participants wore the TomTom Cardio, Microsoft Band and Fitbit Surge on randomly assigned locations on each wrist. The maximum number of monitors per wrist was two. The criteria used for heart rate and energy …

Regulation Of Microvascular Flow And Metabolism: An Overview, Michelle A. Keske, Renee M. Dwyer, Ryan D. Russell, Sarah J. Blackwood, Aascha A. Brown, Donghua Hu, Dino Premilovac, Stephen M. Richards, Stephen Rattigan

Health & Human Performance Faculty Publications and Presentations

Skeletal muscle is an important site for insulin to regulate blood glucose levels. It is estimated that skeletal muscle is responsible for ~80% of insulin-mediated glucose disposal in the post-prandial period. The classical action of insulin to increase muscle glucose uptake involves insulin binding to insulin receptors on myocytes to stimulate glucose transporter 4 (GLUT 4) translocation to the cell surface membrane, enhancing glucose uptake. However, an additional role of insulin that is often under-appreciated is its action to increase muscle perfusion thereby improving insulin and glucose delivery to myocytes. Either of these responses (myocyte and/or vascular) may be impaired …

Collegiate Coaches’ Knowledge Of The Female Athlete Triad In Relation To Their Characteristics, Jillian E. Frideres, Sue G. Mottinger, Jose M. Palao

Health & Human Performance Faculty Publications and Presentations

The purpose of this study was to determine what coaches of female athletes know about the female athlete triad. The sample involved 472 NCAA Division I coaches of female athletes. The variables studied were coaches’ knowledge and confidence about the triad and coaches’ characteristics (coach’s gender, age, type of coach, degree held, years of experience in coaching females, continuing education participation specific to the triad and/or triad components, and sport coached). Coaches’ knowledge of the female athlete triad is higher for coaches who have received triad education. No differences regarding knowledge of the female athlete triad were found by gender, …

Associations Between Pqct-Based Fat And Muscle Area And Density And Dxa-Based Total And Leg Soft Tissue Mass In Healthy Women And Men, V. D. Sherk, R. S. Thiebaud, Z. Chen, Murat Karabulut, S. J. Kim, D. A. Bemben

Health & Biomedical Sciences Faculty Publications and Presentations

Peripheral Quantitative Computed Tomography (pQCT) can be used for muscle and fat area and density assessments. These may independently influence muscle and fat mass measurements from Dual Energy X-ray Absorptiometry (DXA).

Objective

To determine associations between pQCT-derived soft tissue density and area measures and DXA-derived soft tissue mass.

Methods

Linear regression models were developed based on BMI and calf fat and muscle cross-sectional area (FCSA and MCSA) and density measured by pQCT in healthy women (n=76) and men (n=82) aged 20–59 years. Independent variables for these models were leg and total bone-free lean mass (BFLM) and fat mass (FM) measured …

Self-Organizing: From Child’S Play To An Effective Wellness Program, Francisco Guajardo, Brian J. Warren, Lin Wang

Organization and School Leadership Faculty Publications and Presentations

This article examines the exercise practices of a group of faculty members at a regional university who for a decade have participated in their own racquetball league. These professors self-organized their exercise regimen and during the period of their participation have found significant benefits beyond the physical benefits, as a result. Through the production of reflective narratives focused on the impact of their racquetball participation, their self-reported data show two broad themes and numerous sub-themes that emerge from their exercise experience. They reveal significant health benefits, and they express more deeply the benefits of the positive social interaction that impacts …

Health And Human Performance History: 83 Years And Still Going Strong, Judy Walton

UTB/TSC Archives - Health and Human Performance Department History

Word document chronicling the history of the Department of Health and Human Performance from its 1926 beginnings as one of the first departments in the newly founded Junior College of the Lower Rio Grande Valley, to its latest (2008) incarnation as Health & Human Performance at UTB/TSC.

The department began its history as the Physical Education and Athletics Department, which continued until 1978 when the two entities were separated. The Physical Education Department subsequently underwent several name changes until its current designation as the Department of Health and Human Performance. Along with changes of name, the department also experienced many …

Use Of Pedometers To Promote Physical Activity In Older Mexican American Females, Zasha Romero, Paul Villas, Tom Semper, Layne Jorgensen

Health & Human Performance Faculty Publications and Presentations

The rates of obesity and related health conditions are rising at an alarming rate, especially among minority populations. Nutrition and physical activity have been particularly linked to the high rates of heart disease and type 2 diabetes. This study was to determine if pedometers promoted daily walking exercise reflected by changes on selected physiological measurements in older Mexican American females. Significance in the study was determined at the 95% level of confidence. The participants for this study were 55 Mexican American females ages 60 to 75 randomly assigned to a treatment or control group. An analysis of covariance was used …

Activity Determinants Among Mexican American Women In A Border Setting, Bobby Guinn, Vern Vincent

Health & Human Performance Faculty Publications and Presentations

Background: Mexican American women have the highest leisure-time physical inactivity prevalence of any ethnic minority group.

Purpose: This study examined a sample of Mexican American females living near the U.S.-Mexico border to determine whether the variables of age, health status, educational level, marital status, and acculturation distinguished between those who are physically active and those who are physically inactive.

Methods: Participants included 379 women ranging in age from 22 to 58 years. Data was gathered through a self-report survey instrument with discriminant analysis used to test for variable differentiation between active and inactive subjects.

Results: Present …