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Beyond The Baroreflex: A New Measure Of Autonomic Regulation Based On The Time-Frequency Assessment Of Variability, Phase Coherence And Couplings, Philip T. Clemson, Jeffrey B. Hoag, William H. Cooke, Dwain L. Eckberg, Aneta Stefanovska
Beyond The Baroreflex: A New Measure Of Autonomic Regulation Based On The Time-Frequency Assessment Of Variability, Phase Coherence And Couplings, Philip T. Clemson, Jeffrey B. Hoag, William H. Cooke, Dwain L. Eckberg, Aneta Stefanovska
Michigan Tech Publications
For decades the role of autonomic regulation and the baroreflex in the generation of the respiratory sinus arrhythmia (RSA) - modulation of heart rate by the frequency of breathing - has been under dispute. We hypothesized that by using autonomic blockers we can reveal which oscillations and their interactions are suppressed, elucidating their involvement in RSA as well as in cardiovascular regulation more generally. R-R intervals, end tidal CO2, finger arterial pressure, and muscle sympathetic nerve activity (MSNA) were measured simultaneously in 7 subjects during saline, atropine and propranolol infusion. The measurements were repeated during spontaneous and fixed-frequency breathing, and …