Life Sciences Commons^™

The Dose-Response Effect Of Aerobic Exercise On Inflammation In Colon Cancer Survivors, Justin C. Brown, Stephanie L.E. Compton, Jeffrey A. Meyerhardt, Guillaume Spielmann, Shengping Yang

School of Medicine Faculty Publications

Background; Physical activity after surgical resection for colon cancer is associated with significantly longer disease-free survival. Inflammation is hypothesized to mediate the association between physical activity and disease-free survival in colon cancer. Methods; In this exploratory analysis of a randomized dose-response trial, 39 colon cancer survivors who completed standard therapy were stratified by cancer stage and randomized in a 1;1;1 ratio to one of three treatment groups for 24 weeks of usual-care control, 150 min/wk of moderate-intensity aerobic exercise (low-dose), or 300 min/wk of moderate-intensity aerobic exercise (high-dose). Inflammation outcomes included high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL6), and soluble tumor …

Examining The Effects Of Exercise-Induced, Physical Stress Overtraining On Stress Biomarkers In Adolescent, C57bl/6 Mice, Curtis Scotty Davis

Theses, Dissertations and Capstones

Exercise has long been established as a therapeutic modality to improve health and related physical fitness, sports performance, and injury/risk reduction in both adults and adolescents (Haff & Triplett, 2015; Kaminsky, 2010). Nonetheless, there is a lack of research investigating the negative effects of exercise overstress (i.e., overtraining syndrome) in these populations, particularly adolescents (Brenner & American Academy of Pediatrics Council on Sports Medicine and Fitness, 2007; Matos & Winsley, 2007). The objective of this study was to examine hormone biochemical markers, anthropometric markers, and behavioral traits, which are associated with overtraining syndrome, in adolescent C57BL/6 mice. A total of …

Bone, Biomarker, Body Composition, And Performance Responses To 8 Weeks Of Reserve Officers' Training Corps Training, Breanne S. Baker, Samuel R. Buchanan, Christopher D. Black, Michael G. Bemben, Debra A. Bemben

Health & Human Performance Faculty Publications and Presentations

Context: Military personnel engage in vigorous exercise, often resulting in higher bone mineral density; however, leg bone injuries occur frequently in this population. Predictors of change in tibial bone quality and strength need to be characterized in this high-risk population.

Objectives: To examine the effects of an 8-week military training intervention on total body and site-specific bone density and tibial bone quality, serum biomarkers (parathyroid hormone and sclerostin), body composition, and physical performance and to investigate which outcome variables (biomarkers, body composition, and physical performance) predict estimated tibial bone strength in college-aged Reserve Officers' Training Corps (ROTC) participants.

Design: Prospective …

Step Width Variability As A Discriminator Of Age-Related Gait Changes, Andreas Skiadopoulos, Emily E. Moore, Harlan Sayles, Kendra K. Schmid, Nicholas Stergiou

Journal Articles

Background

There is scientific evidence that older adults aged 65 and over walk with increased step width variability which has been associated with risk of falling. However, there are presently no threshold levels that define the optimal reference range of step width variability. Thus, the purpose of our study was to estimate the optimal reference range for identifying older adults with normative and excessive step width variability.

Methods

We searched systematically the BMC, Cochrane Library, EBSCO, Frontiers, IEEE, PubMed, Scopus, SpringerLink, Web of Science, Wiley, and PROQUEST databases until September 2018, and included the studies that measured step width variability …

A Comparison Of Blood Viscosity And Hematocrit Levels Between Yoga Practitioners And Sedentary Adults, James Shadiow, Takashi Tarumi, Mandeep Dhindsa, Stacy D. Hunter

International Journal of Exercise Science

International Journal of Exercise Science 12(2): 425-432, 2019. Elevations in whole blood viscosity (WBV) and hematocrit (Hct), have been linked with increased risk of cardiovascular disease (CVD). Endurance training has been demonstrated to lower WBV and Hct; however, evidence supporting the efficacy of yoga on these measures is sparse. A cross-sectional study was conducted examining WBV and Hct levels between yoga practitioners with a minimum of 3 years of consistent practice and sedentary, healthy adults. Blood samples were collected from a total of 42 participants: 23 sedentary adults and 19 regular yoga practitioners. Brachial arterial blood pressure (BP) was measured …

Do Certain Biomarkers Accurately Reflect Articular Cartilage Change Due To Physical Activity?, Alyssia Evans, Matthew Seeley

Journal of Undergraduate Research

Knee injury and pathology are common problems for Americans who are physically active; they affect half of all Americans who are over the age of 65, and the related annual costs are nearly twenty billion dollars. Knee pain alters running and walking neuromechanics1, and may be deleterious to knee articular cartilage. Researchers have hypothesized that if abnormal gait mechanics, due to knee pain persist, the resulting mechanical and physiological circumstances could influence genesis and progression rate of chronic knee joint pathologies, including knee osteoarthritis.

Utilization Of The Clinical Laboratory For The Implementation Of Concussion Biomarkers In Collegiate Football And The Necessity Of Personalized And Predictive Athlete Specific Reference Intervals, Stefanie Podlog (Nee Schulte), Natalie N. Rasmussen, Joseph W. Mcbeth, Patrick Q. Richards, Eric Yochem, David J. Petron, Frederick G. Strathmann

Athletic Training Collection

Background: A continued interest in concussion biomarkers makes the eventual implementation of identified biomarkers into routine concussion assessment an eventual reality. We sought to develop and test an interdisciplinary approach that could be used to integrate blood-based biomarkers into the established concussion management program for a collegiate football team.

Methods: We used a CLIA-certified laboratory for all testing and chose biomarkers where clinically validated testing was available as would be required for results used in clinical decision making. We summarized the existing methods and results for concussion assessment across an entire season to identify and demonstrate the challenges with the …

Blast Brain Injury Elevates Catecholamine Biosynthesis In The Nucleus Tractus Solitaries And Oxidative Stress In The Hypothalamus In Rats, Nihal Tumer, Stanislav Svetlov, Nataliya Kirichenko, Melissa Whidden, Benedek Erdos, Victor Prima, Alexandra Sherman, Firas H. Kobeissy, Robert Yezierski, Charles Vierck, Kevin Wang

Kinesiology Faculty Publications

Introduction: Traumatic Brain Injury (TBI) produces major health problems impacting the lives of both military and civilian personnel. TBI disrupts autonomic function but the nature of this disruption is unknown. Following blast brain injury, we assessed selective biochemical markers for autonomic function in adult male Sprague Dawley rats. Methods: Rats were subjected to head-directed overpressure blast injury (OBI) of 358 kPa magnitude at the target. At the same time for sham controls, rats were anesthetized as the previous group but instead of OBI were exposed just to noise being placed at ~ 2 m distance from the shock tube nozzle. …

A Meta-Analysis Of Biomarkers Associated With The Overtraining Syndrome, Alissa Donaldson, Frank B. Wyatt, Elise Brown, Tyler Fagan

International Journal of Exercise Science: Conference Proceedings

Overtraining (OT) syndrome has been investigated extensively with little agreement as to reliable markers for detection. A meta-analytic review is a procedure designed to compile studies in an area with hopes of reaching a consensus view. PURPOSE: The purpose of this meta-analysis was to provide summary quantitative findings of biomarkers (i.e., blood) associated with the overtraining syndrome. METHODS: A meta-analytic research design was utilized to investigate selected studies allowing for a coding process to record data. Thirteen studies met inclusion/exclusion criteria. Biomarkers included samples taken with subjects in normal (N) condition and during OT. These biomarkers were the following: glutamine …