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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
If The Beach Boys Were Diabetic, They Would Sing About Good Vibrations!, Peterson Jordan, Brent Feland
If The Beach Boys Were Diabetic, They Would Sing About Good Vibrations!, Peterson Jordan, Brent Feland
Journal of Undergraduate Research
One in every four Americans suffer from Diabetic Neuropathy in the lower extremities. This research has a lot to do with the pain and anguish of one fourth of the American people. This pain can cause depression and other mental illnesses, because it reduces the patient’s physical activity by a land slide. This can be traumatic for the patient and the family. This neuropathy in the lower extremities causes nerve damage in the foot and leg area. Doctors have found that it is due to a lack of blood to the nerves, causing the nerve endings to slowly die. This …
Do Certain Biomarkers Accurately Reflect Articular Cartilage Change Due To Physical Activity?, Alyssia Evans, Matthew Seeley
Do Certain Biomarkers Accurately Reflect Articular Cartilage Change Due To Physical Activity?, Alyssia Evans, Matthew Seeley
Journal of Undergraduate Research
Knee injury and pathology are common problems for Americans who are physically active; they affect half of all Americans who are over the age of 65, and the related annual costs are nearly twenty billion dollars. Knee pain alters running and walking neuromechanics1, and may be deleterious to knee articular cartilage. Researchers have hypothesized that if abnormal gait mechanics, due to knee pain persist, the resulting mechanical and physiological circumstances could influence genesis and progression rate of chronic knee joint pathologies, including knee osteoarthritis.
The Role Of Ip-10 In Muscle Regeneration And Repair After Injury, Jacob Parmley, Robert Hyldahl
The Role Of Ip-10 In Muscle Regeneration And Repair After Injury, Jacob Parmley, Robert Hyldahl
Journal of Undergraduate Research
The repair and regeneration processes of skeletal muscle rely on the activation, proliferation and differentiation of skeletal muscle stem cells (satellite cells), which are necessary sources for muscle increase (hypertrophy) and regeneration (Stewart, 2006). A muscles ability to regenerate diminishes due to age or various diseases, such as muscular dystrophy (Mariol, 2001). Interventions aimed at altering the skeletal muscle environment to optimize muscle stem cell activity and regenerative processes represents a promising approach to enhance muscle regenerative capacity. Recent data from our lab has identified increased levels of the cytokine Interferon Gamma-Inducible Protein 10 (IP-10) during the muscle regenerative period …
Eccentric Vs. Concentric Exercise Intervention During Extreme Post-Surgery Weight Loss, Joshua Kelley, Lance Davidson
Eccentric Vs. Concentric Exercise Intervention During Extreme Post-Surgery Weight Loss, Joshua Kelley, Lance Davidson
Journal of Undergraduate Research
In the past decade severe obesity (body mass index of greater than 35 kg/m²) has increased by 70 percent and is considered the fastest growing BMI category in the United States. Severe obesity has been linked with a low quality of life and a variety of comorbidities. As a result, the amount of various weight loss surgeries have dramatically increased, enabling individuals to lose large amounts of weight in a short period of time. Following Roux-en-Y-Gastric-Bypass surgery, 30-35 percent of the total weight lost is considered muscle mass or fat free mass (FFM) and a 20-40 percent decrease in muscular …
Examining Differences In Gait Between Marketed Below-Knee Prosthetics And Low-Cost Alternatives, Kelly Bickham, Dustin Bruening
Examining Differences In Gait Between Marketed Below-Knee Prosthetics And Low-Cost Alternatives, Kelly Bickham, Dustin Bruening
Journal of Undergraduate Research
Perhaps one of the greatest challenges that accompany the incredible advances in science and technology is making them accessible where they need to be. According to the Amputee Coalition of America (ACA), there are over 2 million American amputees, with an additional 185,000 lower extremity amputees every year [2]. In Africa, Asia and Latin America, where incomes are lower and fewer people are insured, there as many as 30 million amputees. Only a fraction of the world amputee population has access to a prosthetic limb, let alone can afford anything considered state-of-the-art. In order to help address the huge demand, …
Fibroblast Proliferation In Response To Treatment By A Novel Tgf-Beta Pathway Inhibitor, Coray Preece, Robert Hyldahl
Fibroblast Proliferation In Response To Treatment By A Novel Tgf-Beta Pathway Inhibitor, Coray Preece, Robert Hyldahl
Journal of Undergraduate Research
Fibroblasts play a key role in repairing injured tissue by secreting collagen and growth factors into the tissue. In states of disease and overuse, fibroblast activity (i.e. greater fibroblast content and collagen secreting activity) can lead to skeletal muscle fibrosis, in which myofibers are replaced by collagen, decreasing strength and muscle elasticity. It has been shown in previous studies that TGF-beta signaling directly increases fibroblast proliferation and collagen secretion. It has also been shown that inhibition of TGF-beta signaling reduces known symptoms of muscular dystrophies including decreased fibrosis and increased muscular strength. SGI-1252 is a novel small molecule that our …