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Full-Text Articles in Life Sciences
Molecular Mechanisms Underlying Skeletal Muscle Weakness In Human Cancer: Reduced Myosin-Actin Cross-Bridge Formation And Kinetics, Michael Jj. Toth, Mark S. Miller, Damien M. Callahan, Andrew P. Sweeny, Ivette Nunez, Steven M. Grunberg, Hirak Der-Torossian, Marion E. Couch, Kim Dittus
Molecular Mechanisms Underlying Skeletal Muscle Weakness In Human Cancer: Reduced Myosin-Actin Cross-Bridge Formation And Kinetics, Michael Jj. Toth, Mark S. Miller, Damien M. Callahan, Andrew P. Sweeny, Ivette Nunez, Steven M. Grunberg, Hirak Der-Torossian, Marion E. Couch, Kim Dittus
Mark S. Miller
PHYSICAL FUNCTION DETERIORATES substantially following a diagnosis of cancer (3, 48), and patients view this decline as one of the most distressing side effects of the disease, more so than classic side effects such as pain, nausea, and vomiting (13, 60). Functional disability can be the impetus for dose reduction or cessation of anticancer treatments and predicts chemotherapy toxicity and survival (12, 30, 33, 39). Our current understanding of the factors contributing to reduced functional capacity in patients with cancer is, however, severely limited. Physiological changes that occur within the skeletal muscle of patients with cancer can contribute to functional …
Skeletal Muscle Mitochondrial Density, Gene Expression, And Enzyme Activities In Human Heart Failure: Minimal Effects Of The Disease And Resistance Training, Michael J. Toth, Mark S. Miller, Kimberly A. Ward, Philip A. Ades
Skeletal Muscle Mitochondrial Density, Gene Expression, And Enzyme Activities In Human Heart Failure: Minimal Effects Of The Disease And Resistance Training, Michael J. Toth, Mark S. Miller, Kimberly A. Ward, Philip A. Ades
Mark S. Miller
IMPAIRED SKELETAL MUSCLE ENERGETICS in heart failure (HF) patients (32) may contribute to physical disability and metabolic dysfunction. Decreased skeletal muscle oxidative capacity (63), secondary to reduced mitochondrial density (12, 13) and/or function (10, 36, 52), may contribute to exercise intolerance, the hallmark symptom of HF. Moreover, as mitochondrial dysfunction is associated with fiber atrophy (7), impaired energetics may reduce physical function by promoting muscle wasting and, in turn, weakness (21). Because mitochondrial dysfunction has been implicated in the pathophysiology of diabetes (41), alterations in mitochondrial content and/or function could also contribute to the high prevalence of insulin resistance in …
Chronic Heart Failure Reduces Akt Phosphorylation In Human Skeletal Muscle: Relationship To Muscle Size And Function, Michael J. Toth, Kimberly Ward, Jos Van Der Velden, Mark S. Miller, Peter Vanburen, Martin M. Lewinter, Philip A. Ades
Chronic Heart Failure Reduces Akt Phosphorylation In Human Skeletal Muscle: Relationship To Muscle Size And Function, Michael J. Toth, Kimberly Ward, Jos Van Der Velden, Mark S. Miller, Peter Vanburen, Martin M. Lewinter, Philip A. Ades
Mark S. Miller
HEART FAILURE (HF) is the final common pathway for many chronic cardiac diseases and is presently the only cardiac diagnosis continuing to increase in prevalence in the United States. Patients suffering from HF report high rates of physical disability, as defined by an inability to perform simple daily activities (43). Although the reason for their physical disability is unclear, most research has focused on aerobic exercise intolerance in these patients (23). This is logical considering that the hallmark symptom of HF is exertional dyspnea and because of the widespread use of aerobic capacity as a diagnostic tool (36). Diminished aerobic …