Life Sciences Commons^™

Area Of Specialization: Endocrinology And Metabolism Dr. Braun Is Currently Focused On Understanding How Exercise, Dietary Energy/Composition And/Or Pharmacological Agents Interact To Mediate Insulin Resistance And The Risk For Type-2 Diabetes. The American Diabetes Association Is Our Major Source Of Funding For Work On How The Combination Of Exercise And/Or The Drug Metformin Impact Glucose Metabolism And Insulin Sensitivity At The Cellular And Whole-Body Levels. We Also Use Stable Isotope Tracers To Measure The Regulation Of Substrate Kinetics During Exercise. Recent Studies Include The Effects Of Concurrent Energy Surplus And Exercise On Insulin Sensitivity, The Net Impact Of High Body Fat And High Cardiorespiratory Fitness In Women, And The Utility Of Alternative Carbohydrates To Maintain Optimal Blood Glucose Control In Humans With Type-2 Diabetes, Barry Braun

Barry Braun

Results from the Diabetes Prevention Program highlight the effectiveness of metformin or regular physical activity in the prevention of type 2 diabetes. Independently, metformin and exercise increase insulin sensitivity, but they have not been studied in combination. To assess the combined effects, insulinresistant subjects (n = 9) matched for weight, body fat, and aerobic fitness were studied before any treatment (B), after 2–3 wk of 2,000 mg/day metformin (MET), and after metformin plus 40 min of exercise at 65% V ˙ O2peak (MET + Ex). A second group (n = 7) was studied at baseline and after an identical bout …