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Full-Text Articles in Life Sciences
Effects Of Natural Products On Inflammation, Riley Ann Nadler
Effects Of Natural Products On Inflammation, Riley Ann Nadler
MSU Graduate Theses
Chronic inflammation is characterized by infiltration of inflammatory cells such as macrophages and lymphocytes into the tissue where they produce inflammatory cytokines that contribute to tissue damage. Worldwide, 3 out of 5 people die due to chronic inflammatory diseases like cardiovascular diseases, obesity, diabetes, and cancer. Since it is well-documented that diet and metabolism are key mediators of inflammation, I investigated the effects of dietary lectins on inflammatory cytokine production and the ability of sodium pyruvate, a metabolite, to decrease inflammation. In chapter 1, I examined the effect that lectins from either Triticum vulgaris (common wheat) or Phaseolus vulgaris (common …
Bone Morphogenetic Proteins Modulate Mast Cell Responses During Inflammation, Jane S. Woodrow
Bone Morphogenetic Proteins Modulate Mast Cell Responses During Inflammation, Jane S. Woodrow
Doctoral Dissertations
Chronic inflammatory conditions can lead to detrimental health conditions that become difficult to manage and treat. Ultimately treatment requires modulation of the critical cell types involved in pathology in order to achieve homeostasis. Mast cells, a type of innate immune cell located at areas of high antigen load, are commonly thought of as primarily pro-inflammatory, but are becoming increasingly recognized in other roles, such as wound healing, anti-inflammatory actions, and homeostatic functions. In this study we investigate the role of mast cell subtypes and inflammatory mechanisms via in vitro assays using mouse and human mast cells, as well as relate …