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Immunology and Infectious Disease

Theses/Dissertations

Honors Undergraduate Theses

Antibody

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Exploring Interleukin 21 And Its Role In Humoral Immunity In The Mouse Model Of Influenza Infection, Samantha E. Gallahan Jan 2021

Exploring Interleukin 21 And Its Role In Humoral Immunity In The Mouse Model Of Influenza Infection, Samantha E. Gallahan

Honors Undergraduate Theses

In summary, this study will be focused on Il-21 and its implications in the antibody response in influenza. The isotype classes primarily involved in this process will also be examined. This will be accomplished by looking at the serum of mice and analyzing the present influenza specific antibodies using ELISA. Another goal was to optimize the ELISA in order to make it sensitive enough to catch small differences in the results. This topic is important due to its implications for improving influenza vaccinations and preventions as current vaccines are not 100% effective. Influenza contributes to significant disease and death around …