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Full-Text Articles in Life Sciences
Dendritic Cells In Hepatitis C Infection: Can They (Help) Win The Battle, Angela Dolganiuc, Gyongyi Szabo
Dendritic Cells In Hepatitis C Infection: Can They (Help) Win The Battle, Angela Dolganiuc, Gyongyi Szabo
Gyongyi Szabo
Infection with hepatitis C virus (HCV) is a public health problem; it establishes a chronic course in ~85% of infected patients and increases their risk for developing liver cirrhosis, hepatocellular carcinoma, and significant extrahepatic manifestations. The mechanisms of HCV persistence remain elusive and are largely related to inefficient clearance of the virus by the host immune system. Dendritic cells (DCs) are the most efficient inducers of immune responses; they are capable of triggering productive immunity and maintaining the state of tolerance to self- and non-self antigens. During the past decade, multiple research groups have focused on DCs, in hopes of …
Myxoma Virus Induces Type I Interferon Production In Murine Plasmacytoid Dendritic Cells Via A Tlr9/Myd88-, Irf5/Irf7-, And Ifnar-Dependent Pathway, Peihong Dai, Hua Cao, Taha Merghoub, Francesca Avogadri, Weiyi Wang, Tanvi Parikh, Chee-Mun Fang, Paula M. Pitha, Katherine A. Fitzgerald, Masmudur M. Rahman, Grant Mcfadden, Xiaoyu Hu, Alan N. Houghton, Stewart Shuman, Liang Deng
Myxoma Virus Induces Type I Interferon Production In Murine Plasmacytoid Dendritic Cells Via A Tlr9/Myd88-, Irf5/Irf7-, And Ifnar-Dependent Pathway, Peihong Dai, Hua Cao, Taha Merghoub, Francesca Avogadri, Weiyi Wang, Tanvi Parikh, Chee-Mun Fang, Paula M. Pitha, Katherine A. Fitzgerald, Masmudur M. Rahman, Grant Mcfadden, Xiaoyu Hu, Alan N. Houghton, Stewart Shuman, Liang Deng
Katherine A. Fitzgerald
Poxviruses are large DNA viruses that replicate in the cytoplasm of infected cells. Myxoma virus is a rabbit poxvirus that belongs to the Leporipoxvirus genus. It causes a lethal disease called myxomatosis in European rabbits but cannot sustain any detectable infection in nonlagomorphs. Vaccinia virus is a prototypal orthopoxvirus that was used as a vaccine to eradicate smallpox. Myxoma virus is nonpathogenic in mice, whereas systemic infection with vaccinia virus can be lethal even in immunocompetent mice. Plasmacytoid dendritic cells (pDCs) are potent type I interferon (IFN)-producing cells that play important roles in antiviral innate immunity. How poxviruses are sensed …