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Alterations In Ocular Surface System During The Pathogenesis Of Herpes Stromal Keratitis, Pushpa Durgesh Rao
Alterations In Ocular Surface System During The Pathogenesis Of Herpes Stromal Keratitis, Pushpa Durgesh Rao
Wayne State University Dissertations
Herpes stromal keratitis (HSK) is a chronic immuno-inflammatory ocular disease caused by Herpes simplex virus-1 (HSV-1) infection in the cornea. HSK is characterized by the development of corneal opacity and angiogenesis accompanied by the loss of corneal transparency. Despite extensive studies on inhibiting corneal angiogenesis and strategies to reduce HSK disease development, a key underlying mechanism to maintain an intact and a transparent corneal surface during HSK disease progression, remain obscure. Our study has addressed possible causes for the HSK disease severity by identifying the key factors such as the development of inflammatory hypoxia, reduced tear volume, Inflammation of extra-orbital …