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Fundamental Differences In The B Cell Locus, V(D)J Repertoire, And Marburg Virus Epitope Recognition Of The Egyptian Rousette Bat That May Allow For Asymptomatic Presentation, Maggie Linn Bartlett
Fundamental Differences In The B Cell Locus, V(D)J Repertoire, And Marburg Virus Epitope Recognition Of The Egyptian Rousette Bat That May Allow For Asymptomatic Presentation, Maggie Linn Bartlett
Theses & Dissertations
Marburg virus (MARV) causes a hemorrhagic fever in humans but is asymptomatic in a known reservoir, the Egyptian rousette bat (Rousettus aegyptiacus, ERB). Understanding the mechanisms that drive these different outcomes could potentially advance the development of therapeutics. The immunoglobulin (Ig) response to MARV infection in ERBs in known to serve a roll in protection. The Ig germline encodes Variable (VH), Diversity (DH), and Joining (JH) genes that then recombine (V(D)J) to make up the binding site of an Ig. Understanding the gene composition of the Ig germline is critical to defining the potential B cell repertoire. We …