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Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Anti-Inflammatory And Chemopreventive Activity Of Lunasin From Tofu Whey For The Management Of Gastrointestinal Diseases, Cindy Andrea Nieto Veloza
Anti-Inflammatory And Chemopreventive Activity Of Lunasin From Tofu Whey For The Management Of Gastrointestinal Diseases, Cindy Andrea Nieto Veloza
Doctoral Dissertations
Gastrointestinal diseases such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are pathological conditions associated with chronic inflammation, characterized by intestinal damage, debilitating symptoms, and detrimental health consequences. The increased risk of CRC in IBD patients, and the adverse effects associated with current therapeutic strategies, point out the need for safer alternatives to reduce chronic inflammation in the bowel. Lunasin is a bioactive peptide naturally occurring in soybeans, with chemopreventive and anti-inflammatory properties demonstrated in several extra-intestinal diseases. However, to date, there is no evidence of the biological activity of lunasin on the gastrointestinal tract as a target site. …
Rapid Cell Phenotyping Using Array-Based Sensors: Applications In Cancer Stem Cell Therapy And High-Content Screening, Yingying Geng
Rapid Cell Phenotyping Using Array-Based Sensors: Applications In Cancer Stem Cell Therapy And High-Content Screening, Yingying Geng
Doctoral Dissertations
Cell surface harbors rich information regarding the status of cell health. Being able to monitor and detect its changes in response to stimuli will provide crucial information in drug discovery, disease diagnosis, and human health. Despite the efforts and breakthroughs made possible through the specific sensing approach, there are significant challenges in extracting the information on the cell surface in a quantitative and reliable way. To address this challenge, I took the approach of array-based, hypothesis-free sensing in which the engineered sensors selectively interact with target analytes, producing a distinct pattern of response that enables analyte identification. This signature-based pattern …
Bone Morphogenetic Proteins Modulate Mast Cell Responses During Inflammation, Jane S. Woodrow
Bone Morphogenetic Proteins Modulate Mast Cell Responses During Inflammation, Jane S. Woodrow
Doctoral Dissertations
Chronic inflammatory conditions can lead to detrimental health conditions that become difficult to manage and treat. Ultimately treatment requires modulation of the critical cell types involved in pathology in order to achieve homeostasis. Mast cells, a type of innate immune cell located at areas of high antigen load, are commonly thought of as primarily pro-inflammatory, but are becoming increasingly recognized in other roles, such as wound healing, anti-inflammatory actions, and homeostatic functions. In this study we investigate the role of mast cell subtypes and inflammatory mechanisms via in vitro assays using mouse and human mast cells, as well as relate …
Caprine Γδ T Cell Biology, Alehegne W. Yirsaw
Caprine Γδ T Cell Biology, Alehegne W. Yirsaw
Doctoral Dissertations
CAPRINE gd T CELL BIOLOGY AUGUST 2020 ALEHEGNE W YIRSAW, DVM, ADDIS ABABA UNIVERSITY, ETHIOPIA MSC., ADDIS ABABA UNIVERSITY, ETHIOPIA PHD., UNIVERSITY OF MASSACHUSETTS AMHERST DIRECTED BY: PROFESSOR CYNTHIA L BALDWIN Goats are important food animals and are disseminated globally. Their productivity is impacted by infectious diseases thus impacting the livestock owners and the community. γδ T lymphocytes or T cells have vital roles in immune responses in mammals and thus we identified information gaps regarding these cells in goats. We used genome annotation, PCR amplification of genomic DNA and cDNA, and Sanger and PacBio sequencing for this research to …