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The Effects Of Socs1, Socs3 And Hsv-1 Infection On Morphology, Cell Viability And Rab7 Expression In Polarized M1 And M2 Raw 264.7 Murine Macrophages, Jessica Renee Hey
The Effects Of Socs1, Socs3 And Hsv-1 Infection On Morphology, Cell Viability And Rab7 Expression In Polarized M1 And M2 Raw 264.7 Murine Macrophages, Jessica Renee Hey
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HSV-1 causes a life-long infection in its host and has evolved multiple strategies to facilitate infection and evade the immune response. This virus has been found to enter cells by both endocytosis and fusion. The way the virus exploits endocytosis is not fully understood. Recent studies have uncovered roles of Rab GTPases, key regulators in intracellular membrane trafficking pathways, in distinct steps of the HSV-1 life cycle (Raza et al., 2018). This study will focus on analyzing the levels of the late endosomal regulator Rab7 expression in macrophages infected with HSV-1. Revealing the effect of virus on the levels of …