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Full-Text Articles in Life Sciences
Dsrna Conjugated Phytoglycogen Nanoparticles As An Innate Immune Stimulant To Prevent Viral Infections In Rainbow Trout And Atlantic Salmon, Kayla Samms
Theses and Dissertations (Comprehensive)
Salmonids are one of the world’s most farmed fish species. These aquatic vertebrate species rely heavily on their innate immune responses to defend themselves against invading pathogens. Although commercial vaccines are available against some viral and bacterial pathogens affecting salmonids, their protective efficacy is variable. Using a prophylactic inducer of local and systemic innate immune responses could have significant implications in salmonid aquaculture. A potent inducer of the innate immune response in fish is double-stranded RNA (dsRNA), a molecule that all viruses make during their replicative cycle. Polyinosinic:polycytidylic acid (polyI:C) is a synthetic dsRNA commonly used to induce type I …
Investigating The Antitumor Effects Of A Dsrna-Nanoparticle Complex In An In Vitro Ovarian Cancer Model, Aaron Lewis
Investigating The Antitumor Effects Of A Dsrna-Nanoparticle Complex In An In Vitro Ovarian Cancer Model, Aaron Lewis
Theses and Dissertations (Comprehensive)
An estimated 1 in 70 women will be diagnosed with ovarian cancer in their lifetime. Despite advanced detection and treatment methods, it remains a silent killer with an expected survival rate of 50%. A developing method in cancer treatment is the use of compounds that stimulate the immune system to aid in the body's fight against the disease. This project focused on the use of the potent immune stimulant double-stranded RNA (dsRNA), commercially available as polyinosinic:polycytidylic acid, poly(I:C), to induce cytotoxicity in two ovarian cancer cell lines; SKOV-3 and OVCAR-3. Some challenges exist with the delivery of dsRNA due to …