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Immune Responses To Homocitrulline- And Citrulline-Containing Peptides In Rheumatoid Arthritis, Patrick Lac
Immune Responses To Homocitrulline- And Citrulline-Containing Peptides In Rheumatoid Arthritis, Patrick Lac
Electronic Thesis and Dissertation Repository
Anti-citrulline immune responses contribute to rheumatoid arthritis (RA) development, and are linked with the expression of HLA-DR molecules that encode the Shared Epitope (SE). Immune responses to homocitrulline, a structural analog of citrulline, have been recently detected in RA, but their role in RA is unknown.
The objectives of this study were to examine the specificity of anti-homocitrulline antibodies for RA, the dependence of anti-homocitrulline responses on SE-expression, and the cross-reactivity of responses to homocitrulline and citrulline. These objectives were addressed in RA patients and in SE-expressing DR4tg mice using homocitrulline- and citrulline-rich peptides.
Anti-homocitrulline antibodies occurred specifically in RA. …