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Mechanisms Of Protective Activity Of West Nile Virus Anti-Envelope Antibodies In Vitro And In Vivo, Matthew Raymond Vogt
Mechanisms Of Protective Activity Of West Nile Virus Anti-Envelope Antibodies In Vitro And In Vivo, Matthew Raymond Vogt
All Theses and Dissertations (ETDs)
West Nile virus: WNV) is a neurotropic flavivirus capable of causing severe disease and death in humans. Studies in mice have demonstrated that the humoral immune response against WNV limits primary infection and protects against a secondary challenge. Accordingly, passive transfer of immune serum or monoclonal antibodies: MAb) against the envelope: E) protein either prior to WNV infection or shortly thereafter is sufficient to protect mice from disease. The E protein is an immunodominant antigen in the antibody response to WNV infection, and the most potent neutralizing MAbs recognize an epitope on the lateral ridge of domain III: DIII-LR) of …
The Molecular Basis Of Antibody Mediated Neutralization Of Hepatitis C Virus, Michelle Catherine Sabo
The Molecular Basis Of Antibody Mediated Neutralization Of Hepatitis C Virus, Michelle Catherine Sabo
All Theses and Dissertations (ETDs)
Hepatitis C virus: HCV) is positive strand, blood-borne, hepatotropic RNA virus that causes chronic infection in ~170 million people worldwide and is the leading cause of liver transplantation in the United States. HCV entry and attachment is mediated by the envelope protein E2 through interaction with several cellular receptors including CD81, scavenger receptor B1: SRB-1), claudin-1, and occludin, although the exact mechanism by which these receptors facilitate infection remains unclear, largely due to the absence of a structural model of E2. The production of neutralizing antibodies against E2 is thought to be important for controlling HCV infection, likely by blocking …