Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
The Contribution Of Metabolism To The Regulation Of Caspase Activity And Cell Death In T Lymphocytes, Michael Anthony Secinaro
The Contribution Of Metabolism To The Regulation Of Caspase Activity And Cell Death In T Lymphocytes, Michael Anthony Secinaro
Graduate College Dissertations and Theses
During an immune response, T cell activation is mirrored by a dramatic metabolic shift from oxidative phosphorylation to glycolysis. The upregulation of glycolysis allows the cell to generate the molecules needed to rapidly proliferate and to synthesize effector molecules. The resolution of the T cell response is characterized by equally fast death of most effector T cells. The remaining T cells shift back to oxidative phosphorylation, allowing the cell to survive as a memory T cell. The upregulation of glycolysis and proliferation during the effector phase is paralleled by an increased sensitivity to T cell receptor restimulation-induced cell death (RICD). …