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Genetic And Functional Approaches To Understanding Autoimmune And Inflammatory Pathologies, Abbas Raza
Genetic And Functional Approaches To Understanding Autoimmune And Inflammatory Pathologies, Abbas Raza
Graduate College Dissertations and Theses
Our understanding of genetic predisposition to inflammatory and autoimmune diseases has been enhanced by large scale quantitative trait loci (QTL) linkage mapping and genome-wide association studies (GWAS). However, the resolution and interpretation of QTL linkage mapping or GWAS findings are limited. In this work, we complement genetic predictions for several human diseases including multiple sclerosis (MS) and systemic capillary leakage syndrome (SCLS) with genetic and functional data in model organisms to associate genes with phenotypes and diseases.
Focusing on MS, an autoimmune inflammatory disease of the central nervous system (CNS), we experimentally tested the effect of three of the GWAS …