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Full-Text Articles in Life Sciences
Applications Of Bayesian Hierarchical Detection Models, Emily Beasley
Applications Of Bayesian Hierarchical Detection Models, Emily Beasley
Graduate College Dissertations and Theses
Bayesian hierarchical detection models are useful for addressing uncertainty in datasets in the form of detection error and can be adapted to a variety of research questions. This dissertation uses three case studies to highlight advantages of Bayesian hierarchical detection models: 1) using prior information to model undetected species, 2) efficiently modeling a naturally hierarchical system, and 3) correcting for observation bias in two interconnected ecological metrics for effective disease management.Detection error can bias ecological observations, especially when a species is never detected during sampling. In many communities, the probable identity of these species is known from previous research, but …
Functional Characterization Of A Putative Long Non-Coding Rna U90926: Role In Inflammation And Adipose Tissue Homeostasis, Bristy Sabikunnahar
Functional Characterization Of A Putative Long Non-Coding Rna U90926: Role In Inflammation And Adipose Tissue Homeostasis, Bristy Sabikunnahar
Graduate College Dissertations and Theses
Long non-coding RNAs (lncRNAs) are one of the most commonly transcribed functional non-coding RNAs in mammalian genomes, yet majority of them remain understudied. Recent advancement in high throughput sequencing and computational knowledge have revealed the identity of thousands of lncRNAs and their association with numerous diseases and cellular processes. In the last two decades, flurries of studies showed experimentally that lncRNAs regulate a myriad of essential biological processes including immune system. Although a large number of lncRNAs have been identified in a variety of immune cells, only a handful of them have been characterized for biological function and mechanisms. In …
The Role Of Slam-Sap Signaling In The Development Of Innate-Like Gamma Delta (Γδ) T Cells, Somen Kumar Mistri
The Role Of Slam-Sap Signaling In The Development Of Innate-Like Gamma Delta (Γδ) T Cells, Somen Kumar Mistri
Graduate College Dissertations and Theses
Gamma delta (γδ) T cells are unconventional T cells that are highly enriched in the mucosal tissues such as the lung, gut, and skin, where they play critical roles in host immune surveillance, autoimmunity, and anti-tumor immunity. γδ T cells are notable for their ability to rapidly produce large amounts of cytokines such as IL-17 (γδT17), IFN-γ (γδT1), and IL-4 (γδT2). Interestingly, unlike their well-studied conventional αβ T cell counterparts, most γδ T cells acquire their functional programming during specific developmental windows of thymic development using mechanisms that remain unclear. Here, we investigated the role of the SLAM-SAP signaling pathway …