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Full-Text Articles in Life Sciences
Disease Introduction By Aboriginal Humans In North America And The Pleistocene Extinction, Zachary D. Nickell, Matthew D. Moran
Disease Introduction By Aboriginal Humans In North America And The Pleistocene Extinction, Zachary D. Nickell, Matthew D. Moran
Journal of Ecological Anthropology
While overhunting and climate change have been the major hypotheses to explain the late-Pleistocene New World megafaunal extinctions, the role of introduced disease has only received brief attention. Here, we review pre-Columbian diseases endemic to aboriginal Americans and evaluate their potential to cause large-scale mortality in Pleistocene mammals. Of the probable communicable diseases present in pre-Columbian times, we regard anthrax and tuberculosis as viable candidates. These two diseases demonstrate characteristics that could have made them deadly to immunologically naïve populations. Introduced disease, as a primary cause or interacting with overhunting and climate change, could have contributed to the decline and …
Development Of A Non-Invasive Electrode For Intradermal Electrically Mediated Dna Vaccination, Amy Lynn Donate
Development Of A Non-Invasive Electrode For Intradermal Electrically Mediated Dna Vaccination, Amy Lynn Donate
USF Tampa Graduate Theses and Dissertations
Current progress in the development of vaccines has decreased the incidence of fatal and non-fatal infections and increased longevity. However, new technologies need to be developed to combat an emerging generation of infectious diseases. DNA vaccination has been demonstrated to have great potential for use against a wide variety of diseases. Alone, this vaccine technology does not generate a significant immune response for vaccination, but combined with delivery by electroporation (EP), can enhance plasmid expression and immunity against the expressed antigen. Most EP systems, while effective, can be invasive and painful making them less desirable for use in vaccination. Our …