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Full-Text Articles in Life Sciences
Defining The Let-7 Microrna-Mediated Molecular Mechanisms Regulating T Cell Differentiation, Constance C. Angelou
Defining The Let-7 Microrna-Mediated Molecular Mechanisms Regulating T Cell Differentiation, Constance C. Angelou
Doctoral Dissertations
CD4+ and CD8+ T cells are lymphocytes of the adaptive immune system that play essential roles in immunity. Both T cell subsets recognize their cognate antigen through the T cell receptor (TCR), which induces the proliferation and differentiation of these antigen-specific cells into effector T cells. CD4+ T cells have the potential to differentiate into one of multiple lineages of helper T (Th) cells and participate indirectly in antigen clearance by orchestrating the function of other cells. CD8+ T cells differentiate into cytotoxic T lymphocytes (CTL), which directly contributes to the resolution of an infection by …
Let-7 Mirnas Program The Fate Of Cd8 T Cells, Alexandria Wells
Let-7 Mirnas Program The Fate Of Cd8 T Cells, Alexandria Wells
Doctoral Dissertations
CD8 T cells are the cytotoxic effectors of the adaptive immune response, clearing virally infected and cancerous cells within the host. CD8 T cells acquire their cytotoxic function by differentiating into cytotoxic T lymphocytes (CTLs). Once the CTLs have cleared the antigen, the majority of responding cells will die during contraction; however, a small population of the antigen-specific responders will remain, differentiating into long-lived memory cells that provide potent protection to the host upon re-encounter with the antigen. These differentiation programs often become disturbed in cases of chronic infection and cancer. Instead, CD8 T cells are subverted into the so-called …