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Non-Canonical Notch Signaling Regulates Activation And Differentiation Of Peripheral Cd4+ T Cells, Anushka Dongre
Non-Canonical Notch Signaling Regulates Activation And Differentiation Of Peripheral Cd4+ T Cells, Anushka Dongre
Doctoral Dissertations
Cleavage of the Notch receptor via a γ-secretase, results in the release of the active intra-cellular domain of Notch that migrates to the nucleus and interacts with RBP-JΚ, resulting in the activation of downstream target genes. This canonical Notch signaling pathway has been documented to influence T-cell development and function. However, the mechanistic details underlying this process remain obscure. In addition to RBP-JΚ, the intra-cellular domain of Notch also interacts with other proteins in the cytoplasm and nucleus, giving rise to the possibility of an alternate, RBP-JΚ independent Notch pathway. However, the contribution of such RBP-J …