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Full-Text Articles in Life Sciences
The Identification Of Notch1 Functional Domains Responsible For Its Physical Interaction With Pkcθ, Wesley D. Rossiter
The Identification Of Notch1 Functional Domains Responsible For Its Physical Interaction With Pkcθ, Wesley D. Rossiter
Masters Theses
The adaptive immune system is a complex network of cells that protect the body from invasion by foreign pathogens. Crucial to the function of the adaptive immune system is the activation, proliferation and differentiation of T cells in response to foreign pathogen presentation by antigen presenting cells. T cell activation is driven through different signaling pathways that are dependent on phosphorylation of substrates by kinases. In the PLC pathway that activates the il2 gene program, Protein Kinase C-q (PKCq) and Notch1 localize to the immunological synapse and help drive the signaling cascade that leads to robust T cell activation. It …
Design Of Romp-Based Protein Mimics For Sirna Delivery, Brittany M. Deronde
Design Of Romp-Based Protein Mimics For Sirna Delivery, Brittany M. Deronde
Doctoral Dissertations
Designing delivery agents for therapeutics is an ongoing challenge. As treatments and desired cargoes become more complex, the need for improved delivery vehicles becomes critical. Excellent delivery vehicles must ensure the stability of the cargo, maintain the cargo’s solubility, and promote efficient delivery and release. In order to address these issues, many research groups have looked to nature for design inspiration. Proteins, such as HIV-1 TAT and Antennapedia homeodomain protein, are capable of crossing cellular membranes. However, due to the complexities of their structures, they are synthetically challenging to reproduce in the laboratory setting. Being able to incorporate the key …
The Role Of Notch3 Signaling In T Helper Cell Differentiation And Induction Of Eae, Furkan Ayaz
The Role Of Notch3 Signaling In T Helper Cell Differentiation And Induction Of Eae, Furkan Ayaz
Doctoral Dissertations
Th1 and Th17 are subsets of CD4+ T cells or T helper cells (Th). Th cells are the major adaptive immune cells involved in inflammation during the development of Multiple Sclerosis (MS). MS is a neurodegenerative autoimmune disease and one mouse model of the disease is Experimental Autoimmune Encephalomyelitis (EAE). Development and differentiation of Th1 and Th17 cells are regulated by the Notch family of trans-membrane proteins (Notch1, 2, 3 and 4). We and others have shown that pharmacological inhibition of Notch activity impairs Th1 and Th17 differentiation as well as development of EAE. However, it is not known …