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Generating Zika Vaccine Candidates Using Nhumirim Virus As A Backbone, Mariam A. Atobiloye
Generating Zika Vaccine Candidates Using Nhumirim Virus As A Backbone, Mariam A. Atobiloye
Honors Theses
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that is causing significant world-wide health concern. There are currently no treatments or vaccines available for this virus, thus, there is an urgent need to develop a safe and effective vaccine to combat ZIKV infection. Nhumirim virus (NHUV) is also a mosquito-transmitted flavivirus, but it is unable to infect humans and other vertebrate animals, making it an ideal candidate to develop chimeric viral vaccines against other disease-causing flaviviruses, such as ZIKV. In this study, we generated chimeric viruses by replacing envelope (E) gene in the genome of NHUV with ZIKV E gene, which …