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Identification Of Chromatin Regulators Perturbed In Hematopoietic Stem And Progenitor Cell Aging, Eraj S. Khokhar
Identification Of Chromatin Regulators Perturbed In Hematopoietic Stem And Progenitor Cell Aging, Eraj S. Khokhar
Electronic Theses and Dissertations
As lifespan is increasing globally, there is a critical need to identify strategies to extend healthspan and prevent chronic diseases into older age. The long-term goal of my research is to identify novel strategies to ameliorate aging-induced decline in hematopoietic stem cell (HSC) function. HSCs give rise to all mature blood and immune cells. With age, HSCs undergo defects in their differentiation ability which correlates with a decline in immune function. Comprehensive knowledge of gene regulatory and epigenetic mechanisms underlying this defect is a barrier to developing therapies to ameliorate aging-associated decline in HSC function. Therefore, my project focuses on …