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Efficacy And Mechanism Of Â-Defensin2 Fused Antigen Protein Vaccines, Hyun J. Park
Efficacy And Mechanism Of Â-Defensin2 Fused Antigen Protein Vaccines, Hyun J. Park
Dissertations & Theses (Open Access)
Vaccines which use the strategy of fusing adjuvant murine â-defensin2 (mBD2) to an antigen in order to elicit stronger anti-antigen immune responses are referred to as murine â-defensin2 (mBD2) vaccines. Previous studies have validated the potential of mBD2 vaccines, thus in this study we focus on increasing vaccine efficacy as well as mechanism elucidation. Initially, we demonstrate superior IFN-ã release levels by antigen specific effector T cells when antigen is crosspresented by dendritic cells (DC) which absorbed mBD2 vaccine (mBD2 fused antigen protein) over antigen alone. We move unto an in vivo model and note significant increases in the expansion …