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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Bisindolylmaleimide Ix: A Novel Anti-Sars-Cov2 Agent Targeting Viral Main Protease 3clpro Demonstrated By Virtual Screening Pipeline And In-Vitro Validation Assays, Yash Gupta, Dawid Maciorowski, Samantha E. Zak, Krysten A. Jones, Rahul S. Kathayat, Saara-Anne Azizi, Raman Mathur, Catherine M. Pearce, David J. Ilc, Hamza Husein, Andrew S. Herbert, Ajay Bharti, Brijesh Rathi, Ravi Durvasula, Daniel P. Becker, Bryan C. Dickinson, John M. Dye, Prakasha Kempaiah
Bisindolylmaleimide Ix: A Novel Anti-Sars-Cov2 Agent Targeting Viral Main Protease 3clpro Demonstrated By Virtual Screening Pipeline And In-Vitro Validation Assays, Yash Gupta, Dawid Maciorowski, Samantha E. Zak, Krysten A. Jones, Rahul S. Kathayat, Saara-Anne Azizi, Raman Mathur, Catherine M. Pearce, David J. Ilc, Hamza Husein, Andrew S. Herbert, Ajay Bharti, Brijesh Rathi, Ravi Durvasula, Daniel P. Becker, Bryan C. Dickinson, John M. Dye, Prakasha Kempaiah
Chemistry: Faculty Publications and Other Works
SARS-CoV-2, the virus that causes COVID-19 consists of several enzymes with essential functions within its proteome. Here, we focused on repurposing approved and investigational drugs/compounds. We targeted seven proteins with enzymatic activities known to be essential at different stages of the viral cycle including PLpro, 3CLpro, RdRP, Helicase, ExoN, NendoU, and 2′-O-MT. For virtual screening, energy minimization of a crystal structure of the modeled protein was carried out using the Protein Preparation Wizard (Schrodinger LLC 2020-1). Following active site selection based on data mining and COACH predictions, we performed a high-throughput virtual screen of drugs and investigational molecules (n = …
Plasmodium Tlap-2 Is A Microtubule-Associated Protein With Microtubule Stabilization Properties, Grifin Berge
Plasmodium Tlap-2 Is A Microtubule-Associated Protein With Microtubule Stabilization Properties, Grifin Berge
Master's Theses
Microtubules facilitate major cellular and morphological changes in eukaryotic cells, including the protozoan parasite Plasmodium. Microtubule-associated proteins (MAPs), only very few of which have been characterized in the malaria parasite, regulate the highly dynamic microtubules. Thioredoxin-like associated protein 2 (TLAP2) is a MAP unique to the phylum apicomplexa, which in addition to Plasmodium includes the important human pathogen Toxoplasma. Here we report on the cloning and microtubule-binding activity of TLAP2 of the rodent malaria parasite Plasmodium berghei (PbTLAP2). PbTLAP2 is coded by a single exon gene and consists of 598 amino acids. The protein contains a putative C-terminal microtubule-binding domain. …
Investigating The Effects Of Tgf-Β On T Cell Activation-Induced Cell Death, Christina Rose Cunha
Investigating The Effects Of Tgf-Β On T Cell Activation-Induced Cell Death, Christina Rose Cunha
Dissertations
Achieving immune homeostasis requires the functions and numbers of suppressive regulatory T cells (Tregs) and effector conventional T cells (conv T) to be balanced and precisely controlled. A decrease in Treg numbers is associated with autoimmune diseases such as type I diabetes and multiple sclerosis, while Treg numbers are increased in the tumor microenvironment. Conversely, an increase in conv inflammatory T cells in the tumor microenvironment is associated with better outcomes for cancer patients. Thus, maintaining the appropriate balance between Treg and conventional T cell populations is essential for controlling immune responses against non-self and self-antigens, as well as tumor …
Molecular Determinants Of Fetal Tolerance And The Transition To Adult Immunity, Yi Wei Lim
Molecular Determinants Of Fetal Tolerance And The Transition To Adult Immunity, Yi Wei Lim
Dissertations
The perinatal immune system is highly tolerogenic and is phenotypically and functionally distinct from the adult immune system. This tolerogenic nature is a double-edged sword for newborns. While it is beneficial to prevent excessive inflammation against the vast array of foreign antigens encountered after birth, it also causes a lack of immune responses to life-threatening infections. My dissertation research aims to investigate the mechanisms by which perinatal T cells contribute to immune tolerance in infants. A deeper understanding of the nature of the perinatal immune system will provide pivotal knowledge to develop safe and effective strategies to protect infants from …
Analysis Of Regulatory Mechanisms For T Cell Activation, Aleksandra Vuchkovska
Analysis Of Regulatory Mechanisms For T Cell Activation, Aleksandra Vuchkovska
Dissertations
The primary function of the immune system is to seek and eliminate altered or unhealthy cells. T cells are a major component of the immune response and mediate their functions by recognizing specific antigens that allow elimination of infected or neoplastic cells. To avoid inappropriate activation and subsequent immune injuries, T cells have evolved strategies to discriminate self from non-self, or healthy from altered and infected. These strategies rely on the activation of receptors that restrict the T cell response. CD33rSiglecs are a family of mostly inhibitory receptors that bind to sialic acids. Siglecs respond to specific sialic acid patterns …