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Tlr3 Signaling In Human Bdca-3 Dendritic Cells Results In The Formation Of Several Ilt3 And Ilt4 Populations, Nicholas J. Colletti
Tlr3 Signaling In Human Bdca-3 Dendritic Cells Results In The Formation Of Several Ilt3 And Ilt4 Populations, Nicholas J. Colletti
Seton Hall University Dissertations and Theses (ETDs)
Dendritic cells (DCs) represent a population of innate immune cells that are highly efficient at promoting immune responses. DCs are capable of presenting antigens to both CD4 and CD8 T cells. DC presentation and interaction with T cells can result in either immune stimulation or tolerance. This study intends to phenotype a rare subset of DCs found in the human blood and is distinguishable by the expression of various surface markers including: lineage markers (Lin), HLADR, CD1c, and CD141 or BDCA-3. Stimulating BDCA-3 DCs with Poly I:C, a toll-like receptor (TLR) 3 agonist, resulted in the up-regulation of various canonical …