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Full-Text Articles in Life Sciences
Characterizations Of Sars-Cov-2 Mutational Profile, Spike Protein Stability And Viral Transmission, Sayantan Laha, Joyeeta Chakraborty, Shantanab Das, Soumen Kanti Manna, Sampa Biswas, Raghunath Chatterjee
Characterizations Of Sars-Cov-2 Mutational Profile, Spike Protein Stability And Viral Transmission, Sayantan Laha, Joyeeta Chakraborty, Shantanab Das, Soumen Kanti Manna, Sampa Biswas, Raghunath Chatterjee
ISI Best Publications
The recent pandemic of SARS-CoV-2 infection has affected more than 3.0 million people worldwide with more than 200 thousand reported deaths. The SARS-CoV-2 genome has the capability of gaining rapid mutations as the virus spreads. Whole-genome sequencing data offers a wide range of opportunities to study mutation dynamics. The advantage of an increasing amount of whole-genome sequence data of SARS-CoV-2 intrigued us to explore the mutation profile across the genome, to check the genome diversity, and to investigate the implications of those mutations in protein stability and viral transmission. We have identified frequently mutated residues by aligning ~660 SARS-CoV-2 genomes …
Cartography Of Opportunistic Pathogens And Antibiotic Resistance Genes In A Tertiary Hospital Environment, Kern Rei Chng, Chenhao Li, Denis Bertrand, Amanda Hui Qi Ni, Junmei Samantha Kwah, Hwee Meng Low, Chengxuan Tong, Maanasa Natrajan,, Michael Hongjie Zhang,, Licheng Xu, Karrie Kwan Ki Ko, Eliza Xin Pei Ho
Cartography Of Opportunistic Pathogens And Antibiotic Resistance Genes In A Tertiary Hospital Environment, Kern Rei Chng, Chenhao Li, Denis Bertrand, Amanda Hui Qi Ni, Junmei Samantha Kwah, Hwee Meng Low, Chengxuan Tong, Maanasa Natrajan,, Michael Hongjie Zhang,, Licheng Xu, Karrie Kwan Ki Ko, Eliza Xin Pei Ho
ISI Best Publications
Although disinfection is key to infection control, the colonization patterns and resistomes of hospital-environment microbes remain underexplored. We report the first extensive genomic characterization of microbiomes, pathogens and antibiotic resistance cassettes in a tertiary-care hospital, from repeated sampling (up to 1.5 years apart) of 179 sites associated with 45 beds. Deep shotgun metagenomics unveiled distinct ecological niches of microbes and antibiotic resistance genes characterized by biofilm-forming and human-microbiome-influenced environments with corresponding patterns of spatiotemporal divergence. Quasi-metagenomics with nanopore sequencing provided thousands of high-contiguity genomes, phage and plasmid sequences (>60% novel), enabling characterization of resistome and mobilome diversity and dynamic …