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Determination Of Hfe C282y Mutation And Its Association With The Iron Status And Viral Load In Hiv Patients From Reynosa, Tamaulipas, Juan Carlos Hernández, Marisol Rosas Díaz, Esperanza Milagros García Oropesa, Santos Graciela Montemayor Beltrán, Juana Díaz García, Imelda Ramírez Puente
Determination Of Hfe C282y Mutation And Its Association With The Iron Status And Viral Load In Hiv Patients From Reynosa, Tamaulipas, Juan Carlos Hernández, Marisol Rosas Díaz, Esperanza Milagros García Oropesa, Santos Graciela Montemayor Beltrán, Juana Díaz García, Imelda Ramírez Puente
Research Symposium
Background: The HFE protein has a fundamental role in iron homeostasis, the HFE C282Y mutation prevents the specific function of the protein, causing greater intestinal absorption of iron and intracellular accumulation. The HIV virus causes a disease that attacks the cells of the immune system, mainly CD 4 T lymphocytes inducing their destruction and immunosuppression of the patient. Some viruses have the ability to disrupt cellular metabolic processes during their own replication, such is the case of HIV-1, which is involved in alteration of iron metabolism resulting in an overload of iron.
Methods: An exploratory, descriptive, cross-sectional and prolective study …