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Integrating Evolutionary And Functional Approaches To Infer Adaptation At Specific Loci, Jay F. Storz, Christopher W. Wheat
Integrating Evolutionary And Functional Approaches To Infer Adaptation At Specific Loci, Jay F. Storz, Christopher W. Wheat
Jay F. Storz Publications
Inferences about adaptation at specific loci are often exclusively based on the static analysis of DNA sequence variation. Ideally, population-genetic evidence for positive selection serves as a stepping-off point for experimental studies to elucidate the functional significance of the putatively adaptive variation. We argue that inferences about adaptation at specific loci are best achieved by integrating the indirect, retrospective insights provided by population-genetic analyses with the more direct, mechanistic insights provided by functional experiments. Integrative studies of adaptive genetic variation may sometimes be motivated by experimental insights into molecular function, which then provide the impetus to perform population genetic tests …
The Study Of Adaptation And Speciation In The Genomic Era, Jay F. Storz, Hopi E. Hoekstra
The Study Of Adaptation And Speciation In The Genomic Era, Jay F. Storz, Hopi E. Hoekstra
Jay F. Storz Publications
The availability of complete genome sequences and genetic linkage maps for a growing number of mammalian species is opening up exciting new opportunities for studies of evolutionary change in natural populations. For example, multilocus mapping approaches hold the promise of identifying the specific genetic changes that underlie ecological adaptation and reproductive isolation. The fact that many of the genomic resources that have been developed for Mus and Rattus are transferable to other muroid rodents means that roughly 25% of all mammalian species can now be considered ‘‘genome-enabled’’ study organisms to varying degrees. The transferability of genomic resources between model organisms …
Using Genome Scans Of Dna Polymorphism To Infer Adaptive Population Divergence, Jay F. Storz
Using Genome Scans Of Dna Polymorphism To Infer Adaptive Population Divergence, Jay F. Storz
Jay F. Storz Publications
Elucidating the genetic basis of adaptive population divergence is a goal of central importance in evolutionary biology. In principle, it should be possible to identify chromosomal regions involved in adaptive divergence by screening genome-wide patterns of DNA polymorphism to detect the locus-specific signature of positive directional selection. In the case of spatially separated populations that inhabit different environments or sympatric populations that exploit different ecological niches, it is possible to identify loci that underlie divergently selected traits by comparing relative levels of differentiation among large numbers of unlinked markers. In this review I first address the question of whether diversifying …