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Genetic Differences In Hemoglobin Function Between Highland And Lowland Deer Mice, Jay F. Storz, Amy M. Runck, Hideaki Moriyama, Roy E. Weber, Angela Fago
Genetic Differences In Hemoglobin Function Between Highland And Lowland Deer Mice, Jay F. Storz, Amy M. Runck, Hideaki Moriyama, Roy E. Weber, Angela Fago
Jay F. Storz Publications
In high-altitude vertebrates, adaptive changes in blood–O2 affinity may be mediated by modifications of hemoglobin (Hb) structure that affect intrinsic O2 affinity and/or responsiveness to allosteric effectors that modulate Hb–O2 affinity. This mode of genotypic specialization is considered typical of mammalian species that are high-altitude natives. Here we investigated genetically based differences in Hb–O2 affinity between highland and lowland populations of the deer mouse (Peromyscus maniculatus), a generalist species that has the broadest altitudinal distribution of any North American mammal. The results of a combined genetic and proteomic analysis revealed that deer mice harbor …