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The Functional Role Of The Drosophila Gypsy Insulator In The Regulation Of Gene Expression, Hyuck Joon Kang
The Functional Role Of The Drosophila Gypsy Insulator In The Regulation Of Gene Expression, Hyuck Joon Kang
Doctoral Dissertations
Chromatin insulators are short DNA sequences that, together with enhancers and silencers, orchestrate gene transcription through DNA-protein interactions in eukaryotic genomes. It has been proposed that insulators operate at the chromatin level by generating functionally independent higher-order chromatin domains. Insulators may maintain the integrity of such domains using two properties: blocking enhancer-promoter interactions and blocking heterochromatin spreading. The gypsy insulator of Drosophila was identified as a region of the gypsy retrovirus responsible for the production of tissue-specific mutations in many genes. The Suppressor of Hairy wing [Su(Hw)] protein contains 12 zinc fingers that specifically bind the gypsy insulator. Upon DNA …