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Full-Text Articles in Life Sciences
Covid-19 And The Differential Dilemma, Sharlee Climer
Covid-19 And The Differential Dilemma, Sharlee Climer
Computer Science Faculty Works
The conundrums of choosing candidate genes, via differential expression between treated and mock specimens, are tackled by Ghandikota et al. in this issue of Patterns in their efforts to tease out genetic patterns that are characteristic of coronavirus disease 2019 (COVID-19) outcomes.
A Novel Variant In Cmah Is Associated With Blood Type Ab In Ragdoll Cats, Barbara Gandolfi, Robert Grahn, Nicholas Gustafson, Daniela Proverbio, Eva Spada, Badri Adhikari, Janling Cheng, Gordon Andrews, Leslie Lyons, Chris Helps
A Novel Variant In Cmah Is Associated With Blood Type Ab In Ragdoll Cats, Barbara Gandolfi, Robert Grahn, Nicholas Gustafson, Daniela Proverbio, Eva Spada, Badri Adhikari, Janling Cheng, Gordon Andrews, Leslie Lyons, Chris Helps
Computer Science Faculty Works
The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase is associated with the production of sialic acids on cat red blood cells. The cat has one major blood group with three serotypes; the most common blood type A being dominant to type B. A third rare blood type is known as AB and has an unclear mode of inheritance. Cat blood type antigens are defined, with N-glycolylneuraminic acid being associated with type A and N-acetylneuraminic acid with type B. Blood type AB is serologically characterized by agglutination using typing reagents directed against both A and B epitopes. While a genetic characterization of blood …
Human Gephyrin Is Encompassed Within Giant Functional Noncoding Yin–Yang Sequences, Sharlee Climer, Alan Templeton, Weixiong Zhang
Human Gephyrin Is Encompassed Within Giant Functional Noncoding Yin–Yang Sequences, Sharlee Climer, Alan Templeton, Weixiong Zhang
Computer Science Faculty Works
Gephyrin is a highly conserved gene that is vital for the organization of proteins at inhibitory receptors, molybdenum cofactor biosynthesis and other diverse functions. Its specific function is intricately regulated and its aberrant activities have been observed for a number of human diseases. Here we report a remarkable yin–yang haplotype pattern encompassing gephyrin. Yin–yang haplotypes arise when a stretch of DNA evolves to present two disparate forms that bear differing states for nucleotide variations along their lengths. The gephyrin yin–yang pair consists of 284 divergent nucleotide states and both variants vary drastically from their mutual ancestral haplotype, suggesting rapid evolution. …