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Identification Of Proteins That Contribute To Yeast Heat Stress By Lysine Acetylation, Weijia Shi
Identification Of Proteins That Contribute To Yeast Heat Stress By Lysine Acetylation, Weijia Shi
Biological Sciences Undergraduate Honors Theses
Evidence is emerging that protein lysine acetylation may be a novel type of post-translational modification (PTM) contributing to the mechanisms of yeast heat stress responses. Proteomics studies including ours have identified over 1,000 acetylated proteins in the yeast proteomes that are composed of about 6,000 proteins. Our lab recently identified 596 proteins that underwent acetylation changes during heat shock by mass spectrometry. However, the role of lysine acetylation on specific residues of specific proteins in yeast thermotolerance remains largely unknown. This study selected 43 proteins from our lab’s previous work and examined their possible contributions to yeast heat stress responses. …