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Analyzing Adjuvant Radiotherapy Suggests A Non Monotonic Radio-Sensitivity Over Tumor Volumes, Jack Y. Yang, Andrzej Niemierko, Mary Qu Yang, Youping Deng

Faculty Publications

Background: Adjuvant Radiotherapy (RT) after surgical removal of tumors proved beneficial in long-term tumor control and treatment planning. For many years, it has been well concluded that radio-sensitivities of tumors upon radiotherapy decrease according to the sizes of tumors and RT models based on Poisson statistics have been used extensively to validate clinical data. Results: We found that Poisson statistics on RT is actually derived from bacterial cells despite of many validations from clinical data. However cancerous cells do have abnormal cellular communications and use chemical messengers to signal both surrounding normal and cancerous cells to develop new blood vessels …