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Full-Text Articles in Life Sciences
The Lss Supernodulation Mutant In Medicago Truncatula: Genetics, Characterization And Mapping, Arijit Mukherjee
The Lss Supernodulation Mutant In Medicago Truncatula: Genetics, Characterization And Mapping, Arijit Mukherjee
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The symbiotic association between legumes and nitrogen fixing rhizobia culminates in the formation of root nodules. Legumes control the extent of root nodule formation through a regulatory mechanism in which nodulating roots induce a shoot response that signals back to the roots, inhibiting further nodule initiation. Disruption of genes involved in this regulatory process lead to super or hypernodulation. The lss (like sunn supernodulator) mutant of Medicago truncatula has been identified as a naturally occurring supernodulation mutation in the Jemalong cultivar. The phenotype of lss is practically indistinguishable from the phenotype of the previously isolated sunn mutant with respect to …
Functional Genomics Of The Angiotensin Ii Type 2 Receptor In The Developing Brain, Traci Pawlowski
Functional Genomics Of The Angiotensin Ii Type 2 Receptor In The Developing Brain, Traci Pawlowski
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The mammalian brain expresses two angiotensin II specific receptors, the angiotensin II type 1 (AGTR1) and type 2 (AGTR2). Studies in humans and mice indicate a possible role for AGTR2 in learning, memory and behavior. However, AGTR2 gene function in the brain, and the molecular mechanisms by which AGTR2 exerts its physiological action, remains elusive. This study examines the possible role of AGTR2 in the developing brain and in brain function by employing three different approaches.
To identify genes in the developing brain that depend on AGTR2 function, a microarray analysis was conducted that compared the gene expression of Agtr2-/y …
Functional Characterization Of Ectodysplasin-1 And Identification Of Novel Candidate Genes For Ectodermal Dysplasias And Associated Clinical Features, Bradley Griggs
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Ectodermal dysplasias (ED) are a group of developmental disorders in which ectodermally derived structures are abnormally formed or absent entirely. The molecular signaling pathway controlling the differentiation of ectodermal appendages has been well documented in recent years. However, questions remain concerning the key signaling molecule of this pathway, ectodysplasin-1 (EDA), the identity of the EDA signaling pathway's target genes, and the presence of additional phenotypes observed in some patients.
Despite the intensive study of EDA in recent years, the functional significance of the N-terminal intracellular domain of ectodysplasin-1 (N-EDA) has remained elusive. The yeast two-hybrid system was employed to further …
Chloroplast Comparative Genomics: Implications For Phylogeny, Evolution, And Biotechnology, Christopher Saski
Chloroplast Comparative Genomics: Implications For Phylogeny, Evolution, And Biotechnology, Christopher Saski
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Lack of complete chloroplast genome sequences is still a limiting factor determining phylogenetic relationships, discerning evolutionary forces, and extending chloroplast genetic engineering to useful crops. Therefore, the chloroplast genomes from six economically important crops were isolated and sequenced. The results will have an impact on chloroplast biology and biotechnology.
The complete soybean chloroplast genome was compared to the other completely sequenced legumes, Lotus and Medicago. The rpl22 gene was found to be missing from all three legumes, a very informative phylogenetic marker. There is a single, large inversion changing the gene order in the legumes from the typical order found …